Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice.
Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice.
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DOI：
10.1371/journal.pone.0186216
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Su X
中科院分区：
文献类型：
--
作者：
Cui C;Li Y;Gao H;Zhang H;Han J;Zhang D;Li Y;Zhou J;Lu C;Su X
先前的研究证实，鱼油和磷虾油的膳食补充剂可以减轻小鼠的肥胖，但其潜在机制仍不清楚。这项研究的目的是确定油治疗是否会改变肥胖缓解过程中肠道微生物群的结构。ICR小鼠在用标准食物饮食适应两周后连续接受高脂饮食（HFD）12周，用标准食物饮食喂养的小鼠用作对照。与HFD组相比，在接受HFD并补充油的组中，体重增加减弱，肝脏指数，总胆固醇，甘油三酯和低密度脂蛋白胆固醇逐步降低，并且在HFD组中调节的肠道微生物群的整体结构向对照组中发现的结构转移。此外，确定了82个对油处理有反应的改变的操作分类单元，其中19个在与肥胖相关的一个或多个参数上不同。总之，这项研究证实了油治疗对减轻肥胖以及微生物群结构改变的影响。我们建议需要进一步的研究来阐明肥胖缓解和肠道微生物群调节之间的因果关系。
Previous studies confirmed that dietary supplements of fish oil and krill oil can alleviate obesity in mice, but the underlying mechanism remains unclear. This study aims to discern whether oil treatment change the structure of the gut microbiota during the obesity alleviation. The ICR mice received high-fat diet (HFD) continuously for 12 weeks after two weeks of acclimatization with a standard chow diet, and the mice fed with a standard chow diet were used as the control. In the groups that received HFD with oil supplementation, the weight gains were attenuated and the liver index, total cholesterol, triglyceride and low-density lipoprotein cholesterol were reduced stepwise compared with the HFD group, and the overall structure of the gut microbiota, which was modulated in the HFD group, was shifted toward the structure found in the control group. Moreover, eighty-two altered operational taxonomic units responsive to oil treatment were identified and nineteen of them differing in one or more parameters associated with obesity. In conclusion, this study confirmed the effect of oil treatment on obesity alleviation, as well as on the microbiota structure alterations. We proposed that further researches are needed to elucidate the causal relationship between obesity alleviation and gut microbiota modulation.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
3.7
作者：
Armougom F;Henry M;Vialettes B;Raccah D;Raoult D
通讯作者：
Raoult D
DOI：
10.1038/ismej.2014.45
发表时间：
2014-10
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.6
作者：
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通讯作者：
Robinson, Lindsay E.
影响因子：
4.2
作者：
Eknoyan, Garabed
通讯作者：
Eknoyan, Garabed