Spectral Dynamics of Resting State fMRI Within the Ventral Tegmental Area and Dorsal Raphe Nuclei in Medication-Free Major Depressive Disorder in Young Adults.
Spectral Dynamics of Resting State fMRI Within the Ventral Tegmental Area and Dorsal Raphe Nuclei in Medication-Free Major Depressive Disorder in Young Adults.
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DOI：
10.3389/fpsyt.2018.00163
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发表时间：
2018
影响因子：
4.7
通讯作者：
Anand A
中科院分区：
文献类型：
--
作者：
Wohlschläger A;Karne H;Jordan D;Lowe MJ;Jones SE;Anand A
背景资料：中缝背核（DRN）和腹侧被盖区（VTA）是脑干主要的单胺核团，分别由5-羟色胺和多巴胺神经元组成。动物研究表明，当动物表现出类似抑郁的行为时，两个核团的放电模式都会改变。对人类的功能性MRI研究表明，抑郁症患者的VTA激活和DRN连接减少。本研究的目的是首次调查的功能完整性，同时在VTA和DRN在体内人类使用静息状态低频波动fMRI的频谱分析的局部神经元放电。方法：共有97名无药物治疗的受试者-67名无药物治疗的重度抑郁症年轻患者（年龄18-30岁）和30名密切匹配的健康对照者被纳入研究，以检测DRN和VTA的异常动力学。为了调查改变本地化的动力学，我们进行了功率谱分析和以上这两个群体之间的光谱互相关。与此互补的是，在组之间比较了置换熵（一种信息理论测量）的谱依赖性。结果：与对照组相比，患者VTA显示出显著的频谱减慢（p = 0.035，校正）。在DRN中，频谱减慢不太明显，但减慢的量与抑郁严重程度的17项汉密尔顿抑郁评分显著相关（p = 0.038）。通过排列熵评估的信号复杂性显示光谱改变与光谱减慢的结果一致。结论：抑郁症患者VTA和DRN的功能动力学改变可以通过局部fMRI信号检测出来。在此基础上，抗抑郁治疗的影响和治疗反应可以在未来的研究中使用这些标志物进行评估。
Background: Dorsal raphe nucleus (DRN) and ventral tegmental area (VTA) are major brainstem monamine nuclei consisting of serotonin and dopamine neurons respectively. Animal studies show that firing patterns in both nuclei are altered when animals exhibit depression like behaviors. Functional MRI studies in humans have shown reduced VTA activation and DRN connectivity in depression. This study for the first time aims at investigating the functional integrity of local neuronal firing concurrently in both the VTA and DRN in vivo in humans using spectral analysis of resting state low frequency fluctuation fMRI. Method: A total of 97 medication-free subjects—67 medication-free young patients (ages 18–30) with major depressive disorder and 30 closely matched healthy controls were included in the study to detect aberrant dynamics in DRN and VTA. For the investigation of altered localized dynamics we conducted power spectral analysis and above this spectral cross correlation between the two groups. Complementary to this, spectral dependence of permutation entropy, an information theoretical measure, was compared between groups. Results: Patients displayed significant spectral slowing in VTA vs. controls (p = 0.035, corrected). In DRN, spectral slowing was less pronounced, but the amount of slowing significantly correlated with 17-item Hamilton Depression Rating scores of depression severity (p = 0.038). Signal complexity as assessed via permutation entropy showed spectral alterations inline with the results on spectral slowing. Conclusion: Our results indicate that altered functional dynamics of VTA and DRN in depression can be detected from regional fMRI signal. On this basis, impact of antidepressant treatment and treatment response can be assessed using these markers in future studies.
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通讯作者：
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