Prenatal exposure to dexamethasone alters Leydig cell steroidogenic capacity in immature and adult rats.
Prenatal exposure to dexamethasone alters Leydig cell steroidogenic capacity in immature and adult rats.
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产前接触地塞米松会改变未成熟和成年大鼠的 Leydig 细胞类固醇生成能力。
DOI：
10.1002/j.1939-4640.2001.tb03438.x
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Hardy,MP
中科院分区：
文献类型：
--
作者：
Page,KC;Sottas,CM;Hardy,MP
This study examines the effects of prenatal exposure to dexamethasone (DEX) on postnatal testosterone production in male rats. Pregnant female rats were treated on gestation days 14–19 with DEX (100 μg/kg body weight per day; n = 9) or vehicle (n = 9). Results show that 35‐day‐old male offspring from DEX‐treated pregnant females (n = 42) had decreased levels of serum testosterone (45.6% lower,P< .05) compared with control offspring (n = 43), although serum luteinizing hormone (LH) levels were not significantly altered. These findings suggest that a direct programming of developing gonadal cells occurs in response to high levels of maternal glucocorticoid. Indeed, testosterone production was significantly reduced in Leydig cells isolated from immature offspring of DEX‐treated pregnant females compared with controls (48.3%,P< .001), and LH stimulation of these cells did not compensate for the lowered steroidogenic capacity. The hypothalamic‐pituitary‐adrenal axis was also affected, because significant reductions in both serum adrenocorticotropic hormone (ACTH; 26.2%,P< .001) and corticosterone (CORT; 32.3%,P< .001) were measured in DEX‐exposed immature male offspring. In contrast, adult male offspring from DEX‐treated dams had significantly higher levels of serum ACTH (39.2%,P<.001) and CORT (37.8%,P< .001). These same animals had higher serum testosterone (31.6%,P< .05) and a significant reduction in serum LH (30.8%,P< .001). Moreover, Leydig cells isolated from these adult offspring exhibited an increased capacity for testosterone biosynthesis under basal (38.6%,P< .001) and LH‐stimulated conditions (33.5%,P< .001). In summary, sustained changes in steroidogenic capacity were observed in male rats exposed to high levels of glucocorticoid during prenatal development. More specifically, DEX exposure in utero perturbed Leydig cell testosterone production in both pubertal and adult rats.
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DOI：
10.1071/bi9830101
发表时间：
1983
期刊：
Australian journal of biological sciences
影响因子：
--
作者：
Wilson,JD;Griffin,JE;George,FW;Leshin,M
通讯作者：
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影响因子：
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影响因子：
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Joseph Meites
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DOI：
10.1677/joe.0.1070241
发表时间：
1985
期刊：
The Journal of endocrinology
影响因子：
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作者：
I. Pollard;S. Dyer
通讯作者：
S. Dyer