Review: Outcome measures in calcium pyrophosphate deposition.
Review: Outcome measures in calcium pyrophosphate deposition.
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DOI：
10.1016/j.berh.2021.101724
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Tedeschi SK
中科院分区：
文献类型：
--
作者：
Cai K;Tedeschi SK
本综述强调了既往研究中报道的焦磷酸钙沉积（CPPD）患者的结局，并强调了评估这种疾病结局的挑战。先前的CPPD干预临床研究集中在影像学检查的关节损伤和钙化、关节疼痛和肿胀以及炎症生物标志物。CPPD患者和医疗保健提供者的定性访谈还确定了耀斑，整体功能和镇痛药物的使用作为重要的结果。关节损伤和钙化的影像学证据可能是未来CPPD临床研究的结果，尽管CPPD变化的可靠性和敏感性需要进一步测试几种成像方式。CPPD结果测量的挑战包括将体征和症状归因于CPPD与共存形式的关节炎的问题，缺乏预防或溶解焦磷酸钙晶体沉积的疗法，缺乏经验证的患者或医生报告的CPPD结果测量，以及缺乏研究CPPD不同临床表现结果的大型队列。
This review highlights outcomes for patients with calcium pyrophosphate deposition (CPPD) reported in prior studies and underscores challenges to assessing outcomes of this condition. Prior clinical studies of interventions for CPPD focused on joint damage and calcification on imaging tests, joint pain and swelling, and inflammatory biomarkers. Qualitative interviews with patients with CPPD and healthcare providers additionally identified flares, overall function, and use of analgesic medications as important outcomes. Imaging evidence of joint damage and calcification are likely to be outcomes in future clinical studies of CPPD, though reliability and sensitivity to change in CPPD require further testing for several imaging modalities. Challenges to outcome measurement in CPPD include questions of attribution of signs and symptoms to CPPD versus co-existing forms of arthritis, lack of therapies to prevent or dissolve calcium pyrophosphate crystal deposition, absence of validated patient- or physician-reported CPPD outcome measures, and scarcity of large cohorts in which to study outcomes of different clinical presentations of CPPD.
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影响因子：
5
作者：
Cai K;Fuller A;Hensey O;Grossberg D;Christensen R;Shea B;Singh JA;Abhishek A;Tedeschi S;Dalbeth N
通讯作者：
Dalbeth N
影响因子：
4.7
作者：
Bayat, Sara;Aati, Opetaia;Dalbeth, Nicola
通讯作者：
Dalbeth, Nicola
影响因子：
4.7
作者：
Abhishek, A.;Doherty, S.;Doherty, M.
通讯作者：
Doherty, M.
影响因子：
3.9
作者：
Boers, Maarten;Beaton, Dorcas E.;Tugwell, Peter
通讯作者：
Tugwell, Peter
影响因子：
5
作者：
Filippou, Georgios;Pascart, Tristan;Iagnocco, Annamaria
通讯作者：
Iagnocco, Annamaria