Age-related scattered hypofluorescent spots on late-phase indocyanine green angiography: the multimodal imaging and relevant factors.
Age-related scattered hypofluorescent spots on late-phase indocyanine green angiography: the multimodal imaging and relevant factors.
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吲哚菁绿晚相血管造影上年龄相关的散在低荧光斑点：多模态成像及相关因素
DOI：
10.1111/ceo.13306
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发表时间：
2018-11
影响因子：
4
通讯作者：
Wen F
中科院分区：
文献类型：
--
作者：
Chen L;Zhang X;Liu B;Mi L;Wen F
眼底老化及其影像学特征。描述晚期吲哚菁绿血管造影（ASHS - LIA）中年龄相关的分散低荧光斑的人口学特征和多模态成像特征。一项基于医院的回顾性研究。875例正常眼底患者的875只眼接受了吲吲胺绿血管造影（ICGA）、荧光血管造影（FA）、自体荧光（AF）和光谱域光学相干断层扫描（OCT）。回顾了人口统计信息、医疗记录和多模态成像数据。ASHS - LIA直径及其分级，中央凹下脉络膜厚度（SFCT）。33 ~ 87岁（平均65.8±8.4岁）的233例（26.6%）患者被确诊为ASHS‐LIA。与没有ASHS‐LIA的患者相比，ASHS‐LIA患者年龄更大，男性比例更高（均P < 0.001）。ASHS - LIA的发生率和分级随年龄增加而增加（均P < 0.001）。年龄（OR = 1.093）和男性性别（OR = 1.550）是ASHS‐LIA的独立相关因素（P < 0.001, P = 0.002）。息肉样脉络膜血管病变（PCV）患者的ASHS‐LIA发生率最高（53.2%）（均P < 0.001）。ASHS‐LIA主要位于黄斑区（直径100-500 μm），可融合。包括FA、AF和oct在内的多模态成像均未检测到相应的异常。患有和未患有ASHS‐LIA的眼睛的平均SFCT无显著差异（P = 0.221）。晚期ICGA观察到ASHS - LIA，主要位于黄斑区。其他多模态影像学检查（FA、AF、oct）均未发现相应异常。ASHS - LIA的发生率和分级随年龄增加而增加。此外，ASHS‐LIA可能与SFCT无关，但与PCV相关。
Fundus aging and its imaging features. To characterize the demographic and multimodal‐imaging features of age‐related scattered hypofluorescent spots on late‐phase indocyanine green angiography (ASHS‐LIA). A hospital‐based retrospective study. Eight hundred and seventy‐five normal fundi fellow eyes from 875 patients underwent indocyanine green angiography (ICGA), fluorescence angiography (FA), autofluorescence (AF) and spectral‐domain optical coherence tomography (OCT). Demographic information, medical records and multimodal imaging data were reviewed. Diameter of ASHS‐LIA and its grade, subfoveal choroidal thickness (SFCT). ASHS‐LIA was identified in 233 patients (26.6%) aged 33 to 87 years (mean: 65.8 ± 8.4 years). Patients with ASHS‐LIA were significantly older and had a higher male proportion than those without ASHS‐LIA (both P < 0.001). The occurrence and grade of ASHS‐LIA increased with age (all P < 0.001). Age (OR = 1.093) and male gender (OR = 1.550) were the independent relevant factors of ASHS‐LIA (P < 0.001, and P = 0.002, respectively). The incidence of ASHS‐LIA in polypoidal choroidal vasculopathy (PCV) patients (53.2%) was the highest (all P < 0.001). ASHS‐LIA mainly located in macular region (diameter: 100–500 μm), and could be confluent. No corresponding abnormalities were detected via multimodal imaging, including FA, AF and OCT. The mean SFCT had no significant difference between eyes with and without ASHS‐LIA (P = 0.221). ASHS‐LIA was observed on late‐phase ICGA, mainly located in macular region. No corresponding abnormalities were detected by other multimodal imaging, including FA, AF and OCT. The occurrence and grade of ASHS‐LIA increased with age. Moreover, ASHS‐LIA might be not correlated with SFCT, but correlated with PCV.
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影响因子：
4.4
作者：
Chang, AA;Zhu, MD;Billson, F
通讯作者：
Billson, F
影响因子：
3.3
作者：
McCarty, William J.;Chimento, Melissa F.;Johnson, Mark
通讯作者：
Johnson, Mark
影响因子：
3.4
作者：
Chorlay, Aymeric;Thiam, Abdou Rachid
通讯作者：
Thiam, Abdou Rachid
影响因子：
4.4
作者：
Huang, Jiahn-Dar;Curcio, Christine A.;Johnson, Mark
通讯作者：
Johnson, Mark
DOI：
10.1136/bjophthalmol-2011-300344
发表时间：
2011-12
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Curcio CA;Johnson M;Rudolf M;Huang JD
通讯作者：
Huang JD