Differing salivary microbiome diversity, community and diurnal rhythmicity in association with affective state and peripheral inflammation in adults.
Differing salivary microbiome diversity, community and diurnal rhythmicity in association with affective state and peripheral inflammation in adults.
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DOI：
10.1016/j.bbi.2020.02.004
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发表时间：
2020-07
影响因子：
15.1
通讯作者：
Hong, Suzi
中科院分区：
文献类型：
--
作者：
Kohn, Jordan N.;Kosciolek, Tomasz;Marotz, Clarisse;Aleti, Gajender;Guay-Ross, Robert N.;Hong, Seong-Hun;Hansen, Shalisa;Swafford, Austin;Knight, Rob;Hong, Suzi
Interactions between gut microbiota and the host play an important role in central nervous system function and behavior, primarily mediated through immune and neuroendocrine pathways (ie, the gut-brain axis)(Cryan and Dinan, 2012, Liang et al., 2018). Over the past decade, clinical studies and animal models have suggested that chronic distress-related conditions, such as depression and anxiety disorders, are associated with altered gut microbiome composition. For instance, fecal samples from individuals with depression exhibit altered species diversity and taxonomy (Cheung et al., 2019, Horne and Foster, 2018). Various neuropsychiatric conditions are also characterized by under-representation of bacteria that produce anti-inflammatory metabolites (reviewed in Dalile et al., 2019), one potential mechanism by which gut-mediated immune alterations affect behavior. Furthermore, interventions that influence gut-brain interactions may improve depression and anxiety-related symptoms (Bruce-Keller et al., 2018) by altering immune and neuroendocrine pathways, and microbial profiles have been shown to predict treatment responses in mental illness (Mantere et al., 2017).Our current understanding of these relationships is primarily informed by stool-derived specimens, which, though useful, can be limited by practical sampling issues in certain contexts, such as one or fewer specimens per day based on intestinal motility. By comparison, the oral microbiome (eg, salivary, supragingival) is relatively straightforward to collect multiple times per day and can be sampled ‘on-demand,’enabling its investigation in acute laboratory manipulations such as stress reactivity. Although tissue or body-site specific microbiome differences are recognized and such data remain limited, initial reports show modest correlations between oral and gut microbiome composition (Ding and Schloss, 2014, Huttenhower et al., 2012). Oral microbiomes have also been reported to differ in patients with gastrointestinal diseases, such as inflammatory bowel (Said et al., 2014) and celiac disease (Francavilla et al., 2014), as well as inflammatory disorders such as rheumatoid arthritis (Du Teil Espina et al., 2019), and neuropsychiatric disorders, including schizophrenia (Castro-Nallar et al., 2015, Yolken et al., 2015) and Parkinson’s disease (Pereira et al., 2017), as well as obesity (Tam et al., 2018), indicating that diverse pathologies may be reflected in the oral microbiome. What remains unresolved, however, is whether the oral microbiome also serves as a biomarker of subclinical psychological distress or host inflammation, which would provide proof-of-concept for experimental, or observational, investigations of host-microbiome interactions not currently feasible using gut-derived samples.
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DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1126/science.aan4526
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Honda K
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
4.8
作者：
Carmen Collado, Maria;Engen, Phillip A.;Garaulet, Marta
通讯作者：
Garaulet, Marta