Bioactive natural products from Lysobacter.

Bioactive natural products from Lysobacter.
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DOI:
10.1039/c2np20064c
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发表时间:
2012-11
影响因子:
11.9
通讯作者:
Du L
Du L
中科院分区:
化学1区
文献类型:
--
作者:
Xie Y;Wright S;Shen Y;Du L

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滑行革兰氏阴性溶杆菌正在成为一种有前途的新的生物活性天然产物来源。这些无处不在的淡水和土壤微生物生长迅速,易于使用和维护,并且在遗传上适合生物合成工程。本文综述了溶杆菌属的一组具有生物活性和结构独特的天然产物,重点介绍了它们的生物合成。虽然溶杆菌属是已知的生物活性天然产物的多产者,但其酶促组装的详细分子机制研究一直令人惊讶地缺乏。我们希望提供一个快照的溶菌天然产物的重要工作,并提供有用的信息,为未来的生物合成工程的新型抗生素溶杆菌。
The gliding Gram-negative Lysobacter bacteria are emerging as a promising source of new bioactive natural products. These ubiquitous freshwater and soil microorganisms are fast growing, simple to use and maintain, and genetically amenable for biosynthetic engineering. This Highlight reviews a group of biologically active and structurally distinct natural products from the genus Lysobacter, with a focus on their biosyntheses. Although Lysobacter sp. are known as prolific producers of bioactive natural products, detailed molecular mechanistic studies of their enzymatic assembly have been surprisingly scarce. We hope to provide a snapshot of the important work done on the lysobacterial natural products and to provide useful information for future biosynthetic engineering of novel antibiotics in Lysobacter.
DOI: 10.1128/aac.00443-11
发表时间: 2011-08-01
影响因子: 4.9
作者:
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