The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer.
The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer.
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DOI：
10.1038/sj.bjc.6600466
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发表时间：
2002-07-29
影响因子：
8.8
通讯作者：
Milroy, R
中科院分区：
文献类型：
--
作者：
Scott, HR;McMillan, DC;Forrest, LM;Brown, DJF;McArdle, CS;Milroy, R
关键词：
本文研究了不能手术的非小细胞肺癌患者全身炎症反应程度与营养/功能参数的关系。对106例不能手术的非小细胞肺癌(III期和IV期)患者的体重减轻程度、白蛋白、C反应蛋白、功能状态和生活质量进行了测定。生存分析采用COX比例风险模型。大多数患者是男性，几乎80%的患者循环C反应蛋白浓度升高(>；10 mg L−1)。多因素分析显示，年龄(P=0.012)、肿瘤类型(0.002)、体重减轻(P=0.056)、C反应蛋白(P=0.047)、卡诺夫斯基状态(P=0.002)和疲劳(P=0.046)是影响预后的独立因素。根据C反应蛋白浓度的大小(⩽10、11-100和>；100 mg L−1)进行分组。全身炎症反应程度的增加与体重减轻(P=0.004)、白蛋白浓度降低(P=0.001)、运动状态降低(P=0.060)、疲劳增加(P=0.011)和生存率降低(HR 1.936 95%CI 1.414-2.650，P<；0.001)相关。这些结果表明，大多数不能手术的非小细胞肺癌患者有全身炎症反应的证据。此外，全身炎症反应的幅度增加会导致更大的体重减轻、更差的运动状态、更多的疲劳和更差的生存。《英国癌症杂志》(2002)87,264-267。DOI：10.1038/sj.bjc.6600466 www.bjancer.com2002英国癌症研究中心
The relationship between the magnitude of systemic inflammatory response and the nutritional/functional parameters in patients with inoperable non-small cell lung cancer were studied. The extent of weight loss, albumin, C-reactive protein, performance status and quality of life was measured in 106 patients with inoperable non-small cell lung cancer (stages III and IV). Survival analysis was performed using the Cox proportional hazard model. The majority of patients were male and almost 80% had elevated circulating C-reactive protein concentrations (>10 mg l−1). On multivariate analysis, age (P=0.012), tumour type (0.002), weight loss (P=0.056), C-reactive protein (P=0.047), Karnofsky performance status (P=0.002) and fatigue (P=0.046) were independent predictors of survival. The patients were grouped according to the magnitude of the C-reactive protein concentrations (⩽10, 11–100 and >100 mg l−1). An increase in the magnitude of the systemic inflammatory response was associated with increased weight loss (P=0.004), reduced albumin concentrations (P=0.001), reduced performance status (P=0.060), increased fatigue (P=0.011) and reduced survival (HR 1.936 95%CI 1.414–2.650, P<0.001). These results indicate that the majority of patients with inoperable non-small cell lung cancer have evidence of a systemic inflammatory response. Furthermore, an increase in the magnitude of the systemic inflammatory response resulted in greater weight loss, poorer performance status, more fatigue and poorer survival. British Journal of Cancer (2002) 87, 264–267. doi:10.1038/sj.bjc.6600466 www.bjcancer.com © 2002 Cancer Research UK
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影响因子：
8.8
作者：
Scott, HR;McMillan, DC;Crilly, A;McArdle, CS;Milroy, R
通讯作者：
Milroy, R
影响因子：
9.6
作者：
MOUNTAIN, CF
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2.9
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影响因子：
5.3
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