A 6-year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder.
A 6-year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder.
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DOI：
10.1002/gps.5588
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发表时间：
2021-11
影响因子：
4
通讯作者：
Jeuring HW
中科院分区：
文献类型：
--
作者：
Oude Voshaar RC;Dimitriadis M;vandenBrink RHS;Aprahamian I;Borges MK;Marijnissen RM;Hoogendijk EO;Rhebergen D;Jeuring HW
抑郁症已被概念化为加速生物衰老的一种情况。我们将虚弱指数（FI）作为生物衰老的标志物，旨在探索虚弱与抑郁症状或抑郁症之间的双向纵向关联。一项6年随访的队列研究，包括377例患有DSM-IV定义的抑郁症的老年（≥60岁）门诊患者和132例从未抑郁的对照。在基线、2年和6年随访时进行了研究中心访视，并纳入了CIDI 2.0，以评估抑郁障碍和相关协变量。每6个月通过邮件和电话评估抑郁症状的严重程度和死亡率。通过考克斯回归（HRFI = 1.04 [95% CI：1.02-1.06]），对41项FI进行了操作，并根据6年死亡率进行了验证。考克斯回归显示，抑郁症患者的FI越高，缓解机会越低（HRFI = 0.98 [95%CI：0.97-0.99]）。尽管如此，后一种效应在校正基线抑郁症状严重程度后消失。线性混合模型显示，在整个样本中，FI随时间增加（B[SE] = 0.94（0.12），p <0.001），抑郁症状严重程度和抑郁障碍的影响不同。较高的基线抑郁症状严重程度与随着时间的推移FI加速增加的减弱和抑郁障碍相关。抑郁评定量表的总分可能受到虚弱的混淆。根据DSM-IV标准，抑郁症与加速的生物衰老有关。这就要求发展多学科老年护理模式，将虚弱纳入其中，以改善晚期抑郁症的总体结局。为了解开虚弱和抑郁之间的联系，抑郁症应该根据诊断标准进行诊断，因为抑郁症评定量表上的分数会受到虚弱指数的混淆。抑郁症与衰老加速有关，如虚弱指数所示。
Depressive disorder has been conceptualised as a condition of accelerated biological ageing. We operationalised a frailty index (FI) as marker for biological ageing aimed to explore the bidirectional, longitudinal association between frailty and either depressive symptoms or depressive disorder. A cohort study with 6‐year follow‐up including 377 older (≥60 years) outpatients with a DSM‐IV‐defined depressive disorder and 132 never‐depressed controls. Site visits at baseline, 2 and 6‐year follow‐up were conducted and included the CIDI 2.0 to assess depressive disorder and relevant covariates. Depressive symptom severity and mortality were assessed every 6 months by mail and telephone. A 41‐item FI was operationalised and validated against the 6‐year morality rate by Cox regression (HRFI = 1.04 [95% CI: 1.02–1.06]). Cox regression showed that a higher FI was associated with a lower chance of remission among depressed patients (HRFI = 0.98 [95% CI: 0.97–0.99]). Nonetheless, this latter effect disappeared after adjustment for baseline depressive symptom severity. Linear mixed models showed that the FI increased over time in the whole sample (B[SE] = 0.94 (0.12), p < .001) with a differential impact of depressive symptom severity and depressive disorder. Higher baseline depressive symptom severity was associated with an attenuated and depressive disorder with an accelerated increase of the FI over time. The sum score of depression rating scales is likely confounded by frailty. Depressive disorder, according to DSM‐IV criteria, is associated with accelerated biological ageing. This argues for the development of multidisciplinary geriatric care models incorporating frailty to improve the overall outcome of late‐life depression. To disentangle the association between frailty and depression, depression should be diagnosed according to diagnostic criteria, as scores on depression rating scales are confounded by frailty Depressive disorder is associated with accelerated ageing, as indexed by the frailty index
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DOI：
10.1016/j.jamda.2013.10.001
发表时间：
2014-01-01
影响因子：
7.6
作者：
Feng, Liang;Nyunt, Ma Shwe Zin;Ng, Tze Pin
通讯作者：
Ng, Tze Pin
影响因子：
4
作者：
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通讯作者：
Rikkert, Marcel G. M. Olde
影响因子：
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作者：
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Diniz, Breno S.
影响因子：
7.2
作者：
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通讯作者：
Lapane, Kate L.
影响因子：
7.2
作者：
Jeuring, Hans W.;Stek, Max L.;Comijs, Hannie C.
通讯作者：
Comijs, Hannie C.