Dynamic CT perfusion imaging for the detection of crossed cerebellar diaschisis in acute ischemic stroke.
Dynamic CT perfusion imaging for the detection of crossed cerebellar diaschisis in acute ischemic stroke.
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DOI：
10.3348/kjr.2012.13.1.12
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发表时间：
2012-01
影响因子：
4.8
通讯作者：
Brain Research Group
中科院分区：
文献类型：
--
作者：
Jeon YW;Kim SH;Lee JY;Whang K;Kim MS;Kim YJ;Lee MS;Brain Research Group
虽然通过不同的成像方式检测交叉小脑分裂（CCD）已经有了很好的描述，但对其计算机断层扫描灌注成像（CTP）的诊断知之甚少。探讨急性缺血性脑卒中患者CTP影像CCD的检出率及CTP影像上CCD的相关因素。回顾性分析了81例急性缺血性脑卒中患者的脑血容量（CBV）、脑血流量（CBF）、平均传递时间（MTT）和峰值时间（TTP）的CT灌注图。采用切换表技术，采用多通道CT扫描仪获得全脑灌注图。CCD的标准是单侧幕上缺血性病变，并伴有对侧小脑半球灌注减少，根据CTP图进行视觉检查，没有设定阈值。定量分析CCD阳性病例的图。81例中有25例（31%）符合CCD诊断标准。每个CTP图谱的检出率如下：MTT (31%) > TTP (21%) > CBF (9%) > CBV（6%）。在ccd阳性的病例中，幕上缺血体积、灌注减少程度与幕下不对称指数呈强相关（R, 0.555 ~ 0.870），且相关性显著（p < 0.05）。在所有四个基于ctp的地图上都可以检测到CCD。在这些地图中，MTT对CCD的探测最为灵敏。我们的数据表明，CTP成像是诊断急性半脑卒中患者CCD的有效工具。
Although the detection of crossed cerebellar diaschisis (CCD) by means of different imaging modalities is well described, little is known about its diagnosis by computed tomography perfusion (CTP) imaging. We investigated the detection rate of CCD by CTP imaging and the factors related to CCD on CTP images in patients with acute ischemic stroke. CT perfusion maps of cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and time-to-peak (TTP) obtained from 81 consecutive patients affected by an acute ischemic stroke were retrospectively reviewed. Whole-brain perfusion maps were obtained with a multichannel CT scanner using the toggling-table technique. The criteria for CCD was a unilateral supratentorial ischemic lesion and an accompanying decrease in perfusion of the contralateral cerebellar hemisphere on the basis of CTP maps by visual inspection without a set threshold. Maps were quantitatively analyzed in CCD positive cases. The criteria for CCD were fulfilled in 25 of the 81 cases (31%). Detection rates per CTP map were as follows: MTT (31%) > TTP (21%) > CBF (9%) > CBV (6%). Supratentorial ischemic volume, degree of perfusion reduction, and infratentorial asymmetry index correlated strongly (R, 0.555-0.870) and significantly (p < 0.05) with each other in CCD-positive cases. It is possible to detect CCD on all four of the CTP-based maps. Of these maps, MTT is most sensitive in detecting CCD. Our data indicate that CTP imaging is a valid tool for the diagnosis of CCD in patients affected by an acute hemispheric stroke.
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DOI：
10.3174/ajnr.a1435
发表时间：
2009-04
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Lin DD;Kleinman JT;Wityk RJ;Gottesman RF;Hillis AE;Lee AW;Barker PB
通讯作者：
Barker PB
影响因子：
4.8
作者：
Yi, CA;Na, DG;Lee, SJ
通讯作者：
Lee, SJ
影响因子：
5
作者：
Youn, Sung Won;Kim, Jae Hyoung;Bae, Hee-Joon
通讯作者：
Bae, Hee-Joon
影响因子：
6.3
作者：
Sobesky, J;Thiel, A;Heiss, WD
通讯作者：
Heiss, WD
影响因子：
8.3
作者：
INFELD, B;DAVIS, SM;HOPPER, JL
通讯作者：
HOPPER, JL