Urinary and fecal excretion of aromatic amines in pet dogs and cats from the United States.
Urinary and fecal excretion of aromatic amines in pet dogs and cats from the United States.
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DOI：
10.1016/j.envint.2022.107208
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发表时间：
2022-05
影响因子：
11.8
通讯作者：
Kannan, Kurunthachalam
中科院分区：
文献类型：
--
作者：
Chinthakindi, Sridhar;Kannan, Kurunthachalam
几种伯芳胺(AAs)是已知或可疑的致癌物。尽管如此，宠物动物接触到这种化学物质的情况尚不清楚。在这项研究中，我们调查了来自纽约州奥尔巴尼地区的63只宠物尿液(42只狗和21只猫)和77只宠物粪便(37只狗和40只猫)中30种氨基酸和两种烟草化学标志物(尼古丁和可替宁)的出现情况。在38%的犬、猫尿样中检出8种AAs(∑-8AAs)，中位数分别为7.99(0.42~52.3 ng/m L)和31.4(2.63~75.9)ng/m L。在73%的狗和猫的粪便样本中发现了9种氨基酸(∑9AAs)，中位数分别为278(61.78-613 ng/g)和240(55.4-645)ng/g干重量。在30种氨基酸中，2，6-二甲基苯胺(2，6-DMA)在尿样和粪样中的中位数最高。狗和猫尿中尼古丁和可替宁的中位数为0.92 ng/ml，粪便中尼古丁和可替宁的中位数为3.86 ng/g。在AA浓度与宠物年龄或性别之间没有发现显著的相关性。宠物尿液/粪便中的AA和尼古丁浓度之间没有显著的Spearman等级相关性，这表明除了烟草烟雾之外，其他来源对宠物接触AA也有贡献。此外，计算的AAs排泄率高于摄取率，这表明猫和狗暴露于AA前体，如偶氮染料。尿液和粪便中的浓度分别反映了接触AAs的直接和间接接触来源。
Several primary aromatic amines (AAs) are known or suspected carcinogens. Despite this, the exposure of pet animals to this class of chemicals is unknown. In this study, we investigated the occurrence of 30 AAs and two tobacco chemical markers (nicotine and cotinine) in 63 pet urine (42 dog and 21 cat) and 77 pet feces (37 dog and 40 cat) samples collected from the Albany area of New York State. Eight of the 30 AAs (∑8AAs) were found in >38% of dog and cat urine samples, at median concentrations of 7.99 (range: 0.42–52.3 ng/mL) and 31.4 (2.63–75.9) ng/mL, respectively. Nine of the 30 AAs (∑9AAs) were found in >73% of dog and cat feces samples, at median concentrations of 278 (range: 61.7–613 ng/g) and 240 (55.4–645) ng/g dry wt, respectively. Among the 30 AAs, 2,6-dimethylaniline (2,6-DMA) accounted for the highest median concentrations in both urine and fecal samples. Median concentrations of nicotine and cotinine were <0.92 ng/mL in urine and <3.86 ng/g in feces of both dogs and cats. No significant correlation was found between AA concentrations and pet age or gender. The lack of significant Spearman’s rank correlations among the concentrations of AA and nicotine in pet urine/feces suggested that sources other than tobacco smoke contributed to AA exposure in pets. Furthermore, the calculated fecal excretion rates of AAs were higher than the intake rates, which indicates that cats and dogs are exposed to AA precursors such as azo dyes. Concentrations in urine and feces reflected exposure to direct and indirect exposure sources, respectively, of AAs.
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影响因子：
4
作者：
Bugosen S;Mantilla ID;Tarazona-Vasquez F
通讯作者：
Tarazona-Vasquez F
DOI：
10.1016/j.cvsm.2013.05.002
发表时间：
2013-09-01
影响因子：
1.9
作者：
Court, Michael H.
通讯作者：
Court, Michael H.
DOI：
10.1016/j.scitotenv.2021.151395
发表时间：
2022-02-01
期刊：
The Science of the total environment
影响因子：
--
作者：
Chinthakindi S;Zhu Q;Liao C;Kannan K
通讯作者：
Kannan K
影响因子：
4.7
作者：
Matsumoto, Akiko;Matsumoto, Akane;Hara, Megumi
通讯作者：
Hara, Megumi
DOI：
10.1016/j.jchromb.2021.122888
发表时间：
2021-08-15
期刊：
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
影响因子：
--
作者：
Chinthakindi S;Kannan K
通讯作者：
Kannan K