Population coding of somatic sensations.
Population coding of somatic sensations.
复制标题
DOI：
10.1007/s12264-012-1201-2
复制
发表时间：
2012-04
影响因子：
5.6
通讯作者：
Ma, Qiufu
中科院分区：
文献类型：
--
作者：
Ma, Qiufu
躯体感觉系统包括多种感觉形式，例如触觉、疼痛、瘙痒和温度敏感性。这些方式的编码似乎是最好的解释人口编码理论，其中包括以下特点。首先，一个个体的躯体感觉传入与一个特定的神经回路或网络（为简单起见，感觉标记线）连接，其孤立的激活足以在正常条件下产生一种特定的感觉。其次，标记线通过局部兴奋性和抑制性中间神经元相互连接。结果，一条标记线的激活可以调节另一条标记线或提供另一条标记线的栅极控制。第三，大多数感觉纤维都是多模态的，因此放置在皮肤上的给定刺激通常会激活两条或多条感觉标记线;它们之间的串扰需要产生一种主导感觉。第四，在病理条件下，标记线之间的拮抗相互作用的破坏可以打开正常掩蔽的神经元通路，并允许给定的感觉刺激引起新的感觉，如由无害的机械或热刺激引起的疼痛和由疼痛刺激引起的瘙痒。因此，一些感觉纤维在正常与病理条件下沿着沿着不同的标记线工作。因此，更好地理解标记线路串扰背后的神经网络可以提供治疗慢性疼痛和瘙痒的新策略。
The somatic sensory system includes a variety of sensory modalities, such as touch, pain, itch, and temperature sensitivity. The coding of these modalities appears to be best explained by the population-coding theory, which is composed of the following features. First, an individual somatic sensory afferent is connected with a specific neural circuit or network (for simplicity, a sensory-labeled line), whose isolated activation is sufficient to generate one specific sensation under normal conditions. Second, labeled lines are interconnected through local excitatory and inhibitory interneurons. As a result, activation of one labeled line could modulate, or provide gate control of, another labeled line. Third, most sensory fibers are polymodal, such that a given stimulus placed onto the skin often activates two or multiple sensory-labeled lines; crosstalk among them is needed to generate one dominant sensation. Fourth and under pathological conditions, a disruption of the antagonistic interaction among labeled lines could open normally masked neuronal pathways, and allow a given sensory stimulus to evoke a new sensation, such as pain evoked by innocuous mechanical or thermal stimuli and itch evoked by painful stimuli. As a result of this, some sensory fibers operate along distinct labeled lines under normal versus pathological conditions. Thus, a better understanding of the neural network underlying labeled line crosstalk may provide new strategies to treat chronic pain and itch.
登录
查看更多内容
影响因子：
25
作者：
Andrew, D;Craig, AD
通讯作者：
Craig, AD
影响因子：
7.4
作者：
CERVERO, F;IGGO, A;OGAWA, H
通讯作者：
OGAWA, H
影响因子：
13.9
作者：
Costigan M;Scholz J;Woolf CJ
通讯作者：
Woolf CJ
影响因子：
3.5
作者：
Baba, H;Ji, RR;Woolf, CJ
通讯作者：
Woolf, CJ
影响因子：
7.3
作者：
Costa, R.;Marotta, D. M.;Calixto, J. B.
通讯作者：
Calixto, J. B.