CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer.
CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer.
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CXCL11与结肠癌患者的抗肿瘤免疫和改善预后相关。
DOI：
10.3389/fcell.2021.646252
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发表时间：
2021
影响因子：
5.5
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Cao Y;Jiao N;Sun T;Ma Y;Zhang X;Chen H;Hong J;Zhang Y
趋化因子配体C-X-C基序趋化因子配体11（CXCL 11）参与多种癌症的进展，但其在结直肠癌（CRC）中的生物学作用仍然混乱。因此，初步探讨了CXCL 11在结直肠癌中的预后价值及其可能机制。使用三个独立的数据集进行mRNA相关分析：一个数据集来自癌症基因组图谱（TCGA，n = 451），两个单细胞RNA测序（scRNA-seq）数据集来自基因表达综合数据库（GEO）：GSE 146771和GSE 132465。此外，结肠腺癌（COAD）患者队列（一级山医院队列，YJSHC，n = 108）用于通过免疫组织化学分析细胞浸润。我们确定了所有TCGA癌症中肿瘤组织中CXCL 11的分布，发现CXCL 11表达在COAD和直肠腺癌中均显著上调（READ）。然而，CXCL 11 mRNA的上调与COAD的预后较好相关，但与READ无关。在YJSHC中，肿瘤内CXCL 11+细胞丰度高的患者生存期延长（p = 0.001）。此外，我们发现CXCL 11高表达组具有较高比例的抗肿瘤免疫细胞，而较低比例的促肿瘤免疫细胞。此外，我们还发现了CXCL 11介导的基因表达变化和丰富的免疫通路网络。有趣的是，细胞毒性基因（IFNG、GZMA、GZMB、GZMK、GZMM和PRF 1）和免疫抑制分子（包括PD-L1）均与CXCL 11表达呈正相关。CXCL 11可促进抗肿瘤免疫以提高生存率，被认为是COAD患者的独立预后生物标志物。
The chemokine ligand C-X-C motif chemokine ligand 11 (CXCL11) is involved in the progression of various cancers, but its biological roles in colorectal cancer (CRC) remain confused. Therefore, the prognostic value and underlying mechanism of CXCL11 in CRC were preliminarily evaluated. Three independent datasets were used for mRNA-related analysis: one dataset from the Cancer Genome Atlas (TCGA, n = 451) and two single-cell RNA sequencing (scRNA-seq) datasets from Gene Expression Omnibus (GEO): GSE146771 and GSE132465. In addition, a colon adenocarcinoma (COAD) patient cohort (the Yijishan Hospital cohort, YJSHC, n = 108) was utilized for analysis of cell infiltration by immunohistochemistry. We determined the distribution of CXCL11 in tumor tissue across all TCGA cancers and found that CXCL11 expression was significantly upregulated in both COAD and rectal adenocarcinoma (READ). However, the upregulation of CXCL11 mRNA was associated with a better prognosis in COAD, but not in READ. Within the YJSHC, the patients with a high abundance of intratumoral CXCL11+ cells had prolonged survival (p = 0.001). Furthermore, we found that the high CXCL11 expression group had a higher proportion of antitumor immune cells, and a lower proportion of protumor immune cells. Additionally, we discovered the changes of gene expression and enriched immune pathway network mediated by CXCL11. Interestingly, both cytotoxic genes (IFNG, GZMA, GZMB, GZMK, GZMM, and PRF1) and immunosuppressive molecules, including PD-L1, were positively correlated with CXCL11 expression. CXCL11, which promoted antitumor immunity to benefit survival, was identified as an independent prognostic biomarker in patients with COAD.
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影响因子：
7.5
作者：
Ge, Penglei;Wang, Weiwei;Wu, Yang
通讯作者：
Wu, Yang
影响因子：
4
作者：
Gao YJ;Liu L;Li S;Yuan GF;Li L;Zhu HY;Cao GY
通讯作者：
Cao GY
DOI：
10.1084/jem.187.12.2009
发表时间：
1998-06-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cole KE;Strick CA;Paradis TJ;Ogborne KT;Loetscher M;Gladue RP;Lin W;Boyd JG;Moser B;Wood DE;Sahagan BG;Neote K
通讯作者：
Neote K
影响因子：
17.1
作者：
Jonas BA
通讯作者：
Jonas BA
影响因子：
11.8
作者：
Tokunaga R;Zhang W;Naseem M;Puccini A;Berger MD;Soni S;McSkane M;Baba H;Lenz HJ
通讯作者：
Lenz HJ