Adenosine and sleep.
Adenosine and sleep.
复制标题
腺苷和睡眠。
DOI：
10.2174/157015909789152182
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发表时间：
2009-09
影响因子：
5.3
通讯作者：
Greene RW
中科院分区：
文献类型：
--
作者：
Bjorness TE;Greene RW
在过去的几十年中，腺苷（Ado）在睡眠控制中发挥作用的想法被假定在很大程度上是由于药理学研究表明Ado激动剂诱导睡眠和Ado拮抗剂减少睡眠的能力。第二波研究涉及体外细胞分析方法，随后使用神经化学工具，如微透析，确定了脑干和基底前脑唤醒中心内的细胞群，其活动与丘脑皮质激活紧密耦合，并受到Ado的紧张性抑制控制。最近，遗传工具已被用于表明Ado受体调节睡眠的一个关键方面，即慢波睡眠期间表达的慢波活动。本文将简要介绍一些睡眠现象，然后总结Ado水平对睡眠的影响、睡眠对Ado水平的影响，以及最近使用突变小鼠模型来表征Ado在睡眠控制中的作用的实验，最后讨论哪些Ado受体参与了这种控制。综合考虑，这些不同的实验表明，虽然Ado确实在睡眠控制中发挥作用，但它是一种具有特定功能意义的特定作用，并且它是影响睡眠复杂行为的许多神经递质和神经调质之一。最后，由于大多数腺苷相关的实验在睡眠领域都集中在SWS，这篇评论将主要集中在SWS，然而，腺苷在REM睡眠行为的作用将得到解决。
Over the last several decades the idea that adenosine (Ado) plays a role in sleep control was postulated due in large part to pharmacological studies that showed the ability of Ado agonists to induce sleep and Ado antagonists to decrease sleep. A second wave of research involving in vitro cellular analytic approaches and subsequently, the use of neurochemical tools such as microdialysis, identified a population of cells within the brainstem and basal forebrain arousal centers, with activity that is both tightly coupled to thalamocortical activation and under tonic inhibitory control by Ado. Most recently, genetic tools have been used to show that Ado receptors regulate a key aspect of sleep, the slow wave activity expressed during slow wave sleep. This review will briefly introduce some of the phenomenology of sleep and then summarize the effect of Ado levels on sleep, the effect of sleep on Ado levels, and recent experiments using mutant mouse models to characterize the role for Ado in sleep control and end with a discussion of which Ado receptors are involved in such control. When taken together, these various experiments suggest that while Ado does play a role in sleep control, it is a specific role with specific functional implications and it is one of many neurotransmitters and neuromodulators affecting the complex behavior of sleep. Finally, since the majority of adenosine-related experiments in the sleep field have focused on SWS, this review will focus largely on SWS; however, the role of adenosine in REM sleep behavior will be addressed.
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DOI：
10.1016/s0169-328x(99)00219-3
发表时间：
1999-11-10
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Basheer, R;Porkka-Heiskanen, T;McCarley, RW
通讯作者：
McCarley, RW
DOI：
10.1016/0169-328x(92)90173-9
发表时间：
1992-07-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
FINK, JS;WEAVER, DR;REPPERT, SM
通讯作者：
REPPERT, SM
影响因子：
25
作者：
Huang, ZL;Qu, WM;Hayaishi, O
通讯作者：
Hayaishi, O
影响因子：
3.3
作者：
Kalinchuk AV;McCarley RW;Stenberg D;Porkka-Heiskanen T;Basheer R
通讯作者：
Basheer R
影响因子：
5.3
作者：
Arrigoni, E;Rainnie, DG;Greene, RW
通讯作者：
Greene, RW