Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates
Porphyromonas gingivalis and left atrial appendage spontaneous echo contrast in atrial fibrillation ablation candidates
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房颤消融候选人中牙龈卟啉单胞菌和左心耳自发回声对比
DOI：
10.1007/s00380-021-01851-w
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发表时间：
2021
影响因子：
1.5
通讯作者：
Nakano Yukiko
中科院分区：
文献类型：
--
作者：
Miyauchi Shunsuke;Tokuyama Takehito;Shintani Tomoaki;Uotani Yukimi;Miyamoto Shogo;Ikeuchi Yoshihiro;Okamura Sho;Okubo Yousaku;Miyauchi Mutsumi;Nakano Yukiko
心房颤动(AF)与中风和血栓栓塞症的风险是五倍，而血栓栓塞症通常源于左心耳(LAA)。自发性回声对比(SEC)是血栓形成的危险因素，牙龈卟啉单胞菌(P.gigivalis)具有一定的血栓形成作用，在牙周炎和口腔-全身疾病的联系中起着关键作用。我们的目的是澄清P和P之间的关系。房颤患者的牙龈和LAA-SEC。本研究共登记了569名房颤消融者。经食道超声心动图将LAA SEC分为非致密SEC和致密SEC。血清免疫球蛋白G抗体滴度为OFP。采用酶联免疫吸附试验检测牙周炎A亚型(I-IV型)。抗体滴度水平分为高水平(>； 平均 + 3标准差)和低水平。共有513名患者(90%)被纳入非致密SEC组，56名患者(10%)被纳入致密SEC组。多元回归分析显示，高值血清抗体效价为OFP。牙周炎类型II和IV型与致密牙周炎独立相关[类型II：调整后优势比(OR)2.220；95%可信区间(CI)1.062~4.643；P= 0.02；以及类型IV：调整OR 3.169；95%CI 1.058~6.657；P= 0.002]。结果表明，P。在接受适当抗凝治疗的房颤患者中，牙周炎II型和IV型与LAA SEC严重程度相关。
Atrial fibrillation (AF) is associated with a fivefold risk of stroke and thrombotic embolism, which are usually derived from the left atrial appendage (LAA). Spontaneous echo contrast (SEC) is known as a risk factor for thrombosis.Porphyromonas gingivalis(P.gingivalis) has some prothrombotic effects and plays a key role in periodontitis and oral-systemic disease connection. We aimed to clarify the relationship betweenP. gingivalisand LAA SEC among AF patients. A total of 569 AF ablation candidates were enrolled in the present study. LAA SEC was categorized into nondense SEC and dense SEC based on transesophageal echocardiography. Serum immunoglobulin G antibody titers ofP. gingivalisfimA subtypes (types I–IV) were measured with an enzyme-linked immunosorbent assay. The levels of antibody titers were categorized into high (> mean + 3 standard deviation) and low values. A total of 513 (90%) patients were included in the nondense SEC group, and 56 (10%) were included in the dense SEC group. Multivariate regression analysis revealed that the high-value serum antibody titers ofP. gingivalistypes II and IV were independently associated with dense SEC [type II: adjusted odds ratio (OR) 2.220; 95% confidence interval (CI) 1.062–4.643;P= 0.02; and type IV: adjusted OR 3.169; 95% CI 1.058–6.657;P= 0.002]. The results revealed thatP. gingivalistypes II and IV are related to LAA SEC severity among AF patients who receive appropriate anticoagulation therapy.
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