One year of alendronate treatment lowers microstructural stresses associated with trabecular microdamage initiation.
One year of alendronate treatment lowers microstructural stresses associated with trabecular microdamage initiation.
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DOI：
10.1016/j.bone.2010.05.016
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发表时间：
2010-08
期刊：
影响因子：
4.1
通讯作者：
Guldberg, Robert E.
中科院分区：
文献类型：
--
作者：
O'Neal, Jessica M.;Diab, Tamim;Allen, Matthew R.;Vidakovic, Brani;Burr, David B.;Guldberg, Robert E.
阿仑膦酸盐是一种抗骨重塑剂，常用于通过增加骨密度来治疗骨质疏松症。虽然骨折风险降低，但接受阿仑膦酸钠的患者中微损伤累积增加，导致有关重塑抑制对局部组织（材料）性质的潜在有害影响的问题。在这项研究中，对用阿仑膦酸钠治疗一年的比格犬股骨远端的骨小梁核心进行单轴压缩以诱导微损伤，阿仑膦酸钠的剂量按重量比例调整至接近人的阿尔茨海默病和佩吉特病治疗剂量。使用有限元分析计算阿仑膦酸钠治疗和未治疗对照组的组织水平von Mises应力，并与微损伤形态学相关。使用改良版的摩尔和吉布森损伤形态分类法，我们确定阿仑膦酸钠处理的样本与未处理的对照组相比，表现出严重和线性微裂纹模式的小梁的von Mises应力降低约25%（p<0.01），而弥漫性微损伤形成的von Mises应力状态没有降低。此外，对受损骨小梁的结构和结构特征的检查表明，在阿仑膦酸钠治疗的样品中，严重受损的骨小梁比未受损的骨小梁更薄，与负荷轴更对齐，矿化程度更低（p<0.01）。仅在溶剂处理的对照犬中发现了与损伤形态学的相似关系。这些结果表明，与一年的阿仑膦酸钠给药相关的骨结构和基质性质的变化降低了骨小梁抵抗载荷诱导的严重和线性微裂纹形成的能力，这两者在骨折前消耗的能量比扩散损伤少。
Alendronate, an anti-remodeling agent, is commonly used to treat patients suffering from osteoporosis by increasing bone mineral density. Though fracture risk is lowered, an increase in microdamage accumulation has been documented in patients receiving alendronate, leading to questions about the potentially detrimental effects of remodeling suppression on the local tissue (material) properties. In this study, trabecular bone cores from the distal femur of beagle dogs treated for one year with alendronate, at doses scaled by weight to approximate osteoporotic and Paget's disease treatment doses in humans, were subjected to uniaxial compression to induce microdamage. Tissue level von Mises stresses were computed for alendronate-treated and non-treated controls using finite element analysis and correlated to microdamage morphology. Using a modified version of the Moore and Gibson classification for damage morphology, we determined that the von Mises stress for trabeculae exhibiting severe and linear microcrack patterns was decreased by approximately 25% in samples treated with alendronate compared with non-treated controls (p<0.01), whereas there was no reduction in the von Mises stress state for diffuse microdamage formation. Furthermore, an examination of the architectural and structural characteristics of damaged trabeculae demonstrated that severely damaged trabeculae were thinner, more aligned with the loading axis, and less mineralized than undamaged trabeculae in alendronate-treated samples (p<0.01). Similar relationships with damage morphology were found only with trabecular orientation in vehicle-treated control dogs. These results indicate that changes in bone's architecture and matrix properties associated with one year of alendronate administration reduce trabecular bone's ability to resist the formation of loading-induced severe and linear microcracks, both of which dissipate less energy prior to fracture than does diffuse damage.
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影响因子：
158.5
作者：
LIBERMAN, UA;WEISS, SR;KARPF, DB
通讯作者：
KARPF, DB
影响因子：
6.2
作者：
Chapurlat, Roland D.;Arlot, Monique;Delmas, Pierre D.
通讯作者：
Delmas, Pierre D.
影响因子：
4.8
作者：
Aerssens, J;Boonen, S;Dequeker, J
通讯作者：
Dequeker, J
影响因子：
4.1
作者：
Wenzel, TE;Schaffler, MB;Fyhrie, DP
通讯作者：
Fyhrie, DP
影响因子：
4.1
作者：
Nagaraja, Srinidhi;Lin, Angela S. P.;Guldberg, Robert E.
通讯作者：
Guldberg, Robert E.