Glucocorticoids in T cell apoptosis and function.
Glucocorticoids in T cell apoptosis and function.
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DOI：
10.1007/s00018-005-5390-y
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发表时间：
2006-01
影响因子：
8
通讯作者：
Reichardt, HM
中科院分区：
文献类型：
--
作者：
Herold, MJ;McPherson, KG;Reichardt, HM
糖皮质激素（Glucocorticoid，GC）是一类调节多种基本生物学功能的类固醇激素。合成GC的深刻的抗炎和免疫抑制活性，结合其诱导淋巴细胞凋亡的能力，使其成为全球最常用的处方药之一。内源性GCs还发挥广泛的免疫调节活性，包括控制T细胞稳态。大多数，如果不是所有的这些作用是通过糖皮质激素受体，核受体超家族的成员介导的。然而，信号通路及其细胞类型特异性仍然不清楚。在这篇综述中，我们总结了我们目前的知识GC的行动，采用诱导细胞凋亡的机制和目前讨论的模型，他们如何可能参与胸腺细胞的发展。虽然我们在这一领域的知识在近年来大幅增加，我们仍然远远没有一个全面的图片，GC在T淋巴细胞中发挥的作用。
Glucocorticoids (GCs) are a class of steroid hormones which regulate a variety of essential biological functions. The profound anti-inflammatory and immunosuppressive activity of synthetic GCs, combined with their power to induce lymphocyte apoptosis place them among the most commonly prescribed drugs worldwide. Endogenous GCs also exert a wide range of immunomodulatory activities, including the control of T cell homeostasis. Most, if not all of these effects are mediated through the glucocorticoid receptor, a member of the nuclear receptor superfamily. However, the signaling pathways and their cell type specificity remain poorly defined. In this review, we summarize our present knowledge on GC action, the mechanisms employed to induce apoptosis and the currently discussed models of how they may participate in thymocyte development. Although our knowledge in this field has substantially increased during recent years, we are still far from a comprehensive picture of the role that GCs play in T lymphocytes.
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