White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control.
White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control.
复制标题
DOI：
10.1038/s41467-023-37330-1
复制
发表时间：
2023-03-29
影响因子：
16.6
通讯作者：
Boes, Aaron D.
中科院分区：
文献类型：
--
作者：
Jiang, Jiefeng;Bruss, Joel;Lee, Woo-Tek;Tranel, Daniel;Boes, Aaron D.
认知控制调节其他认知功能以实现内部目标，对于适应性行为很重要。认知控制是通过分布在皮质和皮质下区域的神经计算实现的。然而，由于记录白质神经活动的技术挑战，人们对协调支持认知控制的分布式神经计算的白质束的解剖结构知之甚少。在这里，我们利用大量患有局灶性脑损伤的人类患者样本 (n = 643)，并研究病变位置和连接特征如何解释认知控制性能的差异。我们发现，连接多需求网络左额顶叶区域的白质病变可以可靠地预测认知控制表现的缺陷。这些发现增进了我们对白质与认知控制相关性的理解，并提供了一种结合网络断开来预测病变后缺陷的方法。协调认知控制计算的白质束的解剖结构尚不清楚。在这里，作者表明，连接左额顶叶区域的白质病变与认知控制能力缺陷相关。
Cognitive control modulates other cognitive functions to achieve internal goals and is important for adaptive behavior. Cognitive control is enabled by the neural computations distributed over cortical and subcortical areas. However, due to technical challenges in recording neural activity from the white matter, little is known about the anatomy of white matter tracts that coordinate the distributed neural computations that support cognitive control. Here, we leverage a large sample of human patients with focal brain lesions (n = 643) and investigate how lesion location and connectivity profiles account for variance in cognitive control performance. We find that lesions in white matter connecting left frontoparietal regions of the multiple demand network reliably predict deficits in cognitive control performance. These findings advance our understanding of the white matter correlates of cognitive control and provide an approach for incorporating network disconnection to predict deficits following lesions. The anatomy of white matter tracts which coordinate the computations of cognitive control are not well understood. Here, the authors show that lesions in white matter connecting left frontoparietal regions are associated with deficits in cognitive control performance.
登录
查看更多内容
影响因子：
9.8
作者：
Holmes, Avram J.;Hollinshead, Marisa O.;O'Keefe, Timothy M.;Petrov, Victor I.;Fariello, Gabriele R.;Wald, Lawrence L.;Fischl, Bruce;Rosen, Bruce R.;Mair, Ross W.;Roffman, Joshua L.;Smoller, Jordan W.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
25
作者：
Badre, David;Hoffman, Joshua;Cooney, Jeffrey W.;D'Esposito, Mark
通讯作者：
D'Esposito, Mark
影响因子：
5.6
作者：
Boes, Aaron D.;Fischer, David;Fox, Michael D.
通讯作者：
Fox, Michael D.
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T