Early life stress impacts dorsolateral prefrontal cortex functional connectivity in healthy adults: informing future studies of antidepressant treatments.
Early life stress impacts dorsolateral prefrontal cortex functional connectivity in healthy adults: informing future studies of antidepressant treatments.
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DOI：
10.1016/j.jpsychires.2014.01.014
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发表时间：
2014-05
影响因子：
4.8
通讯作者：
Carpenter, Linda L.
中科院分区：
文献类型：
--
作者：
Philip, Noah S.;Valentine, Thomas R.;Sweet, Lawrence H.;Tyrka, Audrey R.;Price, Lawrence H.;Carpenter, Linda L.
关键词：
暴露于早期生活压力（ELS）与不良治疗结果密切相关，特别是对于创伤相关疾病，如抑郁症。然而，到目前为止，很少有研究检查ELS对新治疗（如重复经颅磁刺激（rTMS））结果的潜在影响。这项研究评估了ELS暴露是否会影响与rTMS靶向脑区相关的静息状态功能连接。在两个4分钟的休息时间内，使用3T磁共振成像（MRI）扫描仪对27名无精神病或医学疾病（14名至少有中度ELS病史）的无药物成年人进行扫描。rTMS的主要目标，左，右背外侧前额叶皮层（DLPFC），被用作种子区域的连接分析。相对于对照组，当植入左侧DLPFC时，ELS受试者表现出与左侧额中回的局部连接显著增加，与左侧楔前叶的连接呈负向。ELS状态也与右侧DLPFC到左侧楔前叶和左侧顶下小叶的负连接相关。这些研究结果表明，在有ELS病史的个体中，执行和默认模式网络之间存在更大的分离，这些结果可能会在未来的ELS相关条件的rTMS研究中为神经影像学评估提供信息。
Exposure to early life stress (ELS) is strongly associated with poor treatment outcomes, particularly for trauma-associated disorders such as depression. Little research to date, however, has examined the potential effects of ELS on outcomes with newer treatments, such as repetitive transcranial magnetic stimulation (rTMS). This study evaluated whether ELS exposure impacts resting state functional connectivity associated with brain regions targeted by rTMS. Twenty-seven medication-free adults without psychiatric or medical illness (14 with a history of at least moderate ELS) were scanned using a 3T magnetic resonance imaging (MRI) scanner during two 4-minute rest periods. The primary targets of rTMS, the left and right dorsolateral prefrontal cortex (DLPFC), were utilized as seed regions in connectivity analyses. Relative to controls, when seeding the left DLPFC, ELS subjects demonstrated significantly increased local connectivity with the left middle frontal gyrus and negative connectivity with the left precuneus. ELS status was also associated with negative connectivity from the right DLPFC to the left precuneus and left inferior parietal lobule. These findings demonstrate greater dissociation between the executive and default mode networks in individuals with a history of ELS, and these results may inform neuroimaging assessments in future rTMS studies of ELS-related conditions.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5
作者：
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影响因子：
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作者：
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通讯作者：
Fossati, Philippe
DOI：
10.1017/s1461145705006280
发表时间：
2006-12-01
影响因子：
4.8
作者：
Fregni, Felipe;Marcolin, Marco A.;Pascual-Leone, Alvaro
通讯作者：
Pascual-Leone, Alvaro