Intestinal Microbiota-A Promising Target for Antiviral Therapy?
Intestinal Microbiota-A Promising Target for Antiviral Therapy?
复制标题
肠道菌群-A抗病毒治疗的有希望的靶标？
DOI：
10.3389/fimmu.2021.676232
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发表时间：
2021
影响因子：
7.3
通讯作者：
Zhao M
中科院分区：
文献类型：
--
作者：
Yang M;Yang Y;He Q;Zhu P;Liu M;Xu J;Zhao M
肠道微生物群被认为是对抗肠道病原体的重要生物屏障。然而，它的消耗也对某些病毒感染有疗效，这表明肠道微生物群的不同组成部分可以根据病毒感染的类型发挥促进和抑制作用。微生物群促进或抑制病毒入侵的两种主要机制涉及参与先天和适应性免疫反应以及与病毒的直接或间接相互作用，在此过程中，肠道微生物群的丰度和组成可能被病毒改变。口服益生菌、粪便菌群移植（FMT）和抗生素是调节肠道菌群平衡的主要治疗策略。然而，在临床试验中，这三种方法的疗效有限。因此，肠道菌群可能是一种新的、有前景的抗病毒辅助治疗靶点，更有效、更安全的调节微生物群的方法需要深入研究。本文综述了肠道菌群、抗病毒免疫和病毒之间关系的最新研究进展，以及肠道菌群调控的常用方法，以期对肠道菌群的抗病毒作用提供新的认识。
The intestinal microbiota is thought to be an important biological barrier against enteric pathogens. Its depletion, however, also has curative effects against some viral infections, suggesting that different components of the intestinal microbiota can play both promoting and inhibitory roles depending on the type of viral infection. The two primary mechanisms by which the microbiota facilitates or inhibits viral invasion involve participation in the innate and adaptive immune responses and direct or indirect interaction with the virus, during which the abundance and composition of the intestinal microbiota might be changed by the virus. Oral administration of probiotics, faecal microbiota transplantation (FMT), and antibiotics are major therapeutic strategies for regulating intestinal microbiota balance. However, these three methods have shown limited curative effects in clinical trials. Therefore, the intestinal microbiota might represent a new and promising supplementary antiviral therapeutic target, and more efficient and safer methods for regulating the microbiota require deeper investigation. This review summarizes the latest research on the relationship among the intestinal microbiota, anti-viral immunity and viruses and the most commonly used methods for regulating the intestinal microbiota with the goal of providing new insight into the antiviral effects of the gut microbiota.
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影响因子：
3.7
作者：
Bajaj JS;Heuman DM;Sanyal AJ;Hylemon PB;Sterling RK;Stravitz RT;Fuchs M;Ridlon JM;Daita K;Monteith P;Noble NA;White MB;Fisher A;Sikaroodi M;Rangwala H;Gillevet PM
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作者：
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通讯作者：
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DOI：
10.1073/pnas.1424775112
发表时间：
2015-02-17
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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作者：
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