Interest in treatment with injectable diacetylmorphine among people who use opioids in Baltimore City, Maryland (USA).
Interest in treatment with injectable diacetylmorphine among people who use opioids in Baltimore City, Maryland (USA).
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DOI：
10.1080/07853890.2023.2196435
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发表时间：
2023-12
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
用二乙酰吗啡治疗阿片类药物使用障碍（OUD）是一种基于证据的药物治疗形式，但在美国（US）不可用。更好地了解美国使用阿片类药物（PWUO）的人对注射二乙酰吗啡治疗的可接受性，可能会加快未来旨在让人们参与这种治疗形式的举措。本研究的目的是在美国的PWUO样本中检查与注射二乙酰吗啡治疗相关的因素。数据来自马里兰州巴尔的摩市PWUO的横断面研究。参与者被简短地描述了注射二乙酰吗啡的治疗情况，然后被要求对他们的兴趣程度进行评分。我们使用具有稳健方差的泊松回归来评估与注射二乙酰吗啡治疗相关的因素。参与者的平均年龄为48岁，41%是女性，大多数（76%）是非西班牙裔黑人。最常用的药物是非注射性海洛因（76%）、阿片类止痛药（73%）和非注射性快克/可卡因（73%）。三分之二的参与者（68%）表示对注射二乙酰吗啡治疗感兴趣。与注射用二乙酰吗啡治疗感兴趣显著相关的因素包括：至少受过高中教育（调整患病率比[aPR]: 1.23； 95%可信区间[CI]: 1.04-1.45），没有健康保险（aPR: 1.23; 95% CI: 1.06-1.44），曾经过量用药（aPR: 1.20; 95% CI: 1.01-1.42），以及既往使用阿片类药物治疗障碍（aPR: 1.22; 95% CI: 1.01-1.47）。近期非注射用可卡因与注射用二乙酰吗啡治疗的兴趣呈负相关（aPR 0.80; 95% CI: 0.68-0.94）。在美国使用阿片类药物的人群样本中，对注射二乙酰吗啡治疗的兴趣很高。与注射用二乙酰吗啡治疗的兴趣增加相关的因素包括：至少受过高中教育，曾经过量用药，没有健康保险。过去阿片类药物使用障碍的药物使用与注射二乙酰吗啡治疗的兴趣相关。大多数参与者报告对注射二乙酰吗啡治疗感兴趣。鉴于美国成瘾和过量危机的恶化趋势，注射二乙酰吗啡治疗应被视为治疗OUD的另一种循证选择。
Treatment for opioid use disorder (OUD) with diacetylmorphine is an evidence-based form of drug treatment, but it is not available in the United States (US). Better understanding acceptability of treatment with injectable diacetylmorphine among people who use opioids (PWUO) in the US may expedite future initiatives designed to engage persons in this form of treatment should it become available. The purpose of this research is to examine factors associated with interest in treatment with injectable diacetylmorphine among a sample of PWUO in the US. Data are from a cross-sectional study of PWUO in Baltimore City, Maryland. Participants were given a brief description of treatment with injectable diacetylmorphine and then asked to rate their level of interest. We used Poisson regression with robust variance to assess factors associated with interest in treatment with injectable diacetylmorphine. The average age of participants was 48 years, 41% were women, and most (76%) identified as non-Hispanic, Black. The most commonly used substances were non-injection heroin (76%), opioid pain relievers (73%), and non-injection crack/cocaine (73%). Two-thirds of participants (68%) indicated interest in treatment with injectable diacetylmorphine. Factors significantly associated with interest in injectable diacetylmorphine treatment included: having at least a high school education (adjusted prevalence ratio [aPR]: 1.23; 95% confidence interval [CI]: 1.04–1.45), not having health insurance (aPR: 1.23; 95% CI: 1.06–1.44), having ever overdosed (aPR: 1.20; 95% CI: 1.01–1.42), and past utilization of medications for opioid use disorder (aPR: 1.22; 95% CI: 1.01–1.47). Recent non-injection cocaine use was inversely associated with interest in treatment with injectable diacetylmorphine (aPR 0.80; 95% CI: 0.68–0.94). Interest in treatment with injectable diacetylmorphine was high among a sample of people who use opioids in the United States. Factors associated with increased interest in treatment with injectable diacetylmorphine included having at least a high school education, having ever overdosed, and not having health insurance. Past utilization of medications for opioid use disorder was associated with interest in treatment with injectable diacetylmorphine. The majority of participants reported interest in treatment with injectable diacetylmorphine. Given worsening trends in the addiction and overdose crisis in the US, treatment with injectable diacetylmorphine should be considered as another evidence-based option for treating OUD.
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影响因子：
5.5
作者：
Lofwall MR;Walsh SL
通讯作者：
Walsh SL
对患者和提供者对阿片类药物使用障碍的治疗药物的观点的系统评价。
影响因子：
3.9
作者：
Cioe K;Biondi BE;Easly R;Simard A;Zheng X;Springer SA
通讯作者：
Springer SA
影响因子：
4.4
作者：
Meyer M;Eichenberger R;Strasser J;Dürsteler KM;Vogel M
通讯作者：
Vogel M
影响因子：
168.9
作者：
Degenhardt, Louisa;Grebely, Jason;Larney, Sarah
通讯作者：
Larney, Sarah
影响因子：
4.2
作者：
Morral, AR;Belding, MA;Iguchi, MY
通讯作者：
Iguchi, MY