Emerging Roles for G Protein-Coupled Estrogen Receptor 1 in Cardio-Renal Health: Implications for Aging.
Emerging Roles for G Protein-Coupled Estrogen Receptor 1 in Cardio-Renal Health: Implications for Aging.
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DOI：
10.3390/biom12030412
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发表时间：
2022-03-07
期刊：
影响因子：
5.5
通讯作者：
Gohar EY
中科院分区：
文献类型：
--
作者：
Singh R;Nasci VL;Guthrie G;Ertuglu LA;Butt MK;Kirabo A;Gohar EY
心血管（CV）和肾脏疾病在美国和全球越来越普遍。在美国，与cv相关的死亡率是导致死亡的主要原因，而与肾脏相关的死亡率排在第8位。尽管有先进的治疗方法，但这两种疾病仍然存在，需要继续探索疾病机制，以开发新的治疗方法，并推进心肾健康的临床结果。CV和肾脏疾病随年龄增长而增加，且CV和肾脏疾病的患病率和进展均存在明显的性别差异。心肾健康方面的这些年龄和性别差异暗示性激素作为潜在的重要调节因子有待研究。其中一个调节因子是G蛋白偶联雌激素受体1 （GPER1）。GPER1与雌激素信号有关，并在包括心脏、血管和肾脏在内的多种组织中表达。在不同的实验动物模型中，GPER1已被证明对CV和肾脏疾病具有保护作用。GPER1的作用涉及多种信号通路：与醛固酮和内皮素-1信号相互作用，刺激一氧化氮的释放，减少氧化应激、炎症和免疫浸润。这篇综述将讨论当前关于GPER1和心肾健康的文献，特别是在衰老的背景下。提高我们对gper1诱发机制的理解可能会揭示新的治疗方法，旨在改善老年人的心肾健康和临床结果。
Cardiovascular (CV) and renal diseases are increasingly prevalent in the United States and globally. CV-related mortality is the leading cause of death in the United States, while renal-related mortality is the 8th. Despite advanced therapeutics, both diseases persist, warranting continued exploration of disease mechanisms to develop novel therapeutics and advance clinical outcomes for cardio-renal health. CV and renal diseases increase with age, and there are sex differences evident in both the prevalence and progression of CV and renal disease. These age and sex differences seen in cardio-renal health implicate sex hormones as potentially important regulators to be studied. One such regulator is G protein-coupled estrogen receptor 1 (GPER1). GPER1 has been implicated in estrogen signaling and is expressed in a variety of tissues including the heart, vasculature, and kidney. GPER1 has been shown to be protective against CV and renal diseases in different experimental animal models. GPER1 actions involve multiple signaling pathways: interaction with aldosterone and endothelin-1 signaling, stimulation of the release of nitric oxide, and reduction in oxidative stress, inflammation, and immune infiltration. This review will discuss the current literature regarding GPER1 and cardio-renal health, particularly in the context of aging. Improving our understanding of GPER1-evoked mechanisms may reveal novel therapeutics aimed at improving cardio-renal health and clinical outcomes in the elderly.
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DOI：
10.1056/nejmoa1000485
发表时间：
2010-07-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Basaria S;Coviello AD;Travison TG;Storer TW;Farwell WR;Jette AM;Eder R;Tennstedt S;Ulloor J;Zhang A;Choong K;Lakshman KM;Mazer NA;Miciek R;Krasnoff J;Elmi A;Knapp PE;Brooks B;Appleman E;Aggarwal S;Bhasin G;Hede-Brierley L;Bhatia A;Collins L;LeBrasseur N;Fiore LD;Bhasin S
通讯作者：
Bhasin S
影响因子：
3.3
作者：
Abdel-Kader K;Palevsky PM
通讯作者：
Palevsky PM
影响因子：
45.3
作者：
Armstrong, Gregory T.;Kawashima, Toana;Oeffinger, Kevin C.
通讯作者：
Oeffinger, Kevin C.
DOI：
10.1590/s0100-879x2002000900008
发表时间：
2002-09-01
影响因子：
2.3
作者：
Barp, J.;Araújo, A.S.R.;Singal, P.
通讯作者：
Singal, P.
影响因子：
8.3
作者：
Barton, M;Cosentino, F;Luscher, TF
通讯作者：
Luscher, TF