Enhanced activity of the left precuneus as a predictor of visuospatial dysfunction correlates with disease activity in rheumatoid arthritis.
Enhanced activity of the left precuneus as a predictor of visuospatial dysfunction correlates with disease activity in rheumatoid arthritis.
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DOI：
10.1186/s40001-023-01224-1
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发表时间：
2023-08-09
影响因子：
4.2
通讯作者：
Ma, Shuhua
中科院分区：
文献类型：
--
作者：
Zheng, Yanmin;Xie, Lei;Huang, Zikai;Peng, Jianhua;Huang, Shuxin;Guo, Ruiwei;Huang, Jinzhuang;Lin, Zhirong;Zhuang, Zelin;Yin, Jingjing;Hou, Zhiduo;Ma, Shuhua
旨在通过基于心理旋转任务（MRT）的功能磁共振成像（fMRI），识别类风湿关节炎（RA）的潜在诊断生物标志物，并评估RA患者视觉空间功能障碍与疾病活动度之间的关系。
本研究共纳入27例RA患者（11例病情缓解，16例病情活动）和27例匹配良好的健康对照者。采用MRT测量受试者的视觉空间功能。在MRT过程中，运用血氧水平依赖性功能磁共振成像技术采集脑活动数据。使用疾病活动度评分28（DAS28）评估RA患者的疾病严重程度。对视觉空间相关脑区异常、MRT表现与DAS28之间的相关性进行分析。
RA患者在MRT中的表现较健康对照者差。与健康对照组相比，RA患者在旋转任务中左侧楔前叶、左侧额上回和右侧扣带回的激活增强，且以左侧大脑半球为主。与病情缓解的RA患者相比，病情活动的RA患者左侧楔前叶、左侧额中回和右侧扣带回的激活增强。RA患者左侧楔前叶的激活与MRT准确率呈负相关（r = -0.621，p = 0.01），与DAS28呈正相关（r = 0.710，p = 0.002），且RA患者的MRT准确率与DAS28呈负相关（r = -0.702，p = 0.002）。
RA患者左侧楔前叶激活增强影响视觉空间功能，且与疾病活动度密切相关。这些变化可能为RA提供有价值的诊断性神经影像学生物标志物。
To identify the potential diagnostic biomarkers of rheumatoid arthritis (RA) and assess the relation between visuospatial dysfunction and disease activity in RA patients using mental rotation task (MRT)-based functional magnetic resonance imaging (fMRI). A total of 27 RA patients (11 in remission, 16 in active) and 27 well-matched controls were enrolled. The visuospatial function of the subjects was measured by MRT. Brain activity data were collected using blood oxygen level dependent fMRI technique under MRT. Disease activity score 28 (DAS28) was used to evaluate the disease severity of RA patients. An analysis of the correlations between abnormal visuospatial-related brain regions, MRT performance, and DAS28 was conducted. RA patients performed worse on MRT than controls. Compared to the control group, RA patients showed enhanced activation in the left precuneus, left superior frontal gyrus and right cingulate gyrus during the rotation task, with left hemisphere dominance. RA patients in active showed enhanced activation in the left precuneus, left middle frontal gyrus and right cingulate gyrus compared to the patients in remission. The left precuneus activation was negatively correlated with MRT accuracy (r = −0.621, p = 0.01) and positively correlated with DAS28 (r = 0.710, p = 0.002), and MRT accuracy was negatively correlated with DAS28 in RA patients (r = −0.702, p = 0.002). Enhanced activation of the left precuneus in RA patients affects visuospatial function and is closely related to disease activity. These changes may provide a valuable diagnostic neuroimaging biomarker of RA.
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影响因子：
2.5
作者：
Corballis, PM
通讯作者：
Corballis, PM
DOI：
10.1016/b978-0-444-53485-9.00004-0
发表时间：
2016-01-01
期刊：
NEUROIMAGING, PT I
影响因子：
--
作者：
Buchbinder, Bradley R.
通讯作者：
Buchbinder, Bradley R.
影响因子：
3.7
作者：
Gerardin, E;Sirigu, A;Le Bihan, D
通讯作者：
Le Bihan, D
影响因子：
4
作者：
Pamuk, Omer Nuri;Kisacik, Bunyamin;Keystone, Edward C.
通讯作者：
Keystone, Edward C.
影响因子：
5.7
作者：
Grefkes, C;Ritzl, A;Fink, GR
通讯作者：
Fink, GR