Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients.

Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients.
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DOI:
10.1364/oe.17.003884
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发表时间:
2009-03-02
期刊:
影响因子:
3.8
通讯作者:
Detre JA
Detre JA
中科院分区:
物理与天体物理2区
文献类型:
--
作者:
Durduran T;Zhou C;Edlow BL;Yu G;Choe R;Kim MN;Cucchiara BL;Putt ME;Shah Q;Kasner SE;Greenberg JH;Yodh AG;Detre JA

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“漫相关光谱”(DCS)是一种可与“近红外光谱”(NIRS)混合的无创经颅脑血流量(CBF)测量技术。总的来说,这些方法具有监测中风患者血流动力学的潜力。我们探索了 DCS 和 NIRS 的实用性,以测量影响额叶皮层的急性缺血性卒中患者和对照组中 30°、15°、0°、-5° 和 0° 角度床头 (HOB) 定位的效果。 HOB 定位显着改变了 CBF、氧合血红蛋白 (HbO2) 和总血红蛋白 (THC) 浓度。此外,同侧梗塞的存在对所有参数都有显着影响。结果与梗死半球 CBF 自动调节受损的概念一致。
“Diffuse correlation spectroscopy” (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with “near-infrared spectroscopy” (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30°, 15°, 0°, −5° and 0° angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (HbO2) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.
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