Calibration of patient-specific boundary conditions for coupled CFD models of the aorta derived from 4D Flow-MRI.
Calibration of patient-specific boundary conditions for coupled CFD models of the aorta derived from 4D Flow-MRI.
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DOI：
10.3389/fbioe.2023.1178483
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发表时间：
2023
影响因子：
5.7
通讯作者：
Kazakidi, Asimina
中科院分区：
文献类型：
--
作者：
Black, Scott MacDonald;Maclean, Craig;Hall Barrientos, Pauline;Ritos, Konstantinos;McQueen, Alistair;Kazakidi, Asimina
前言：特定于患者的计算流体动力学(CFD)模型可以分析主动脉夹层(AD)患者复杂的主动脉内血流动力学，其中血管形态和疾病严重程度高度个性化。这些模型中的模拟血流状态对规定的边界条件(BCS)很敏感，因此准确的边界条件选择是获得临床相关结果的基础。方法：本研究提出了一种新的降维计算框架，用于基于流的迭代校准三元Windkesel模型(3EWM)参数，以生成患者特定的BCS。使用回溯性四维Flow磁共振成像(4D Flow-MRI)获得的时间分辨血流信息来校准这些参数。对于健康和解剖的病例，然后在完全耦合的零维-三维(0D-3D)数值框架下对血流进行数值研究，其中血管几何形状由医学图像重建。3EWM参数的校准是自动化的，每个分支需要约3.5分钟。结果：根据校正的BCS公式，计算的近壁血流动力学(时间平均壁切应力、振荡切变指数)和血流灌注分布与临床测量和先前的文献一致，产生了生理学上的相关结果。BC校准在AD情况下尤其重要，在AD情况下，只有在BC校准之后才能捕获复杂的流型。讨论：因此，这种校准方法可以应用于已知分支流速的临床病例中，例如，通过4D Flow-MRI或超声，为CFD模型生成患者特定的BCS。然后，就可以通过CFD逐一阐明由于主动脉病变的几何变化而产生的高度个性化的血流动力学。
Introduction: Patient-specific computational fluid dynamics (CFD) models permit analysis of complex intra-aortic hemodynamics in patients with aortic dissection (AD), where vessel morphology and disease severity are highly individualized. The simulated blood flow regime within these models is sensitive to the prescribed boundary conditions (BCs), so accurate BC selection is fundamental to achieve clinically relevant results. Methods: This study presents a novel reduced-order computational framework for the iterative flow-based calibration of 3-Element Windkessel Model (3EWM) parameters to generate patient-specific BCs. These parameters were calibrated using time-resolved flow information derived from retrospective four-dimensional flow magnetic resonance imaging (4D Flow-MRI). For a healthy and dissected case, blood flow was then investigated numerically in a fully coupled zero dimensional-three dimensional (0D-3D) numerical framework, where the vessel geometries were reconstructed from medical images. Calibration of the 3EWM parameters was automated and required ~3.5 min per branch. Results: With prescription of the calibrated BCs, the computed near-wall hemodynamics (time-averaged wall shear stress, oscillatory shear index) and perfusion distribution were consistent with clinical measurements and previous literature, yielding physiologically relevant results. BC calibration was particularly important in the AD case, where the complex flow regime was captured only after BC calibration. Discussion: This calibration methodology can therefore be applied in clinical cases where branch flow rates are known, for example, via 4D Flow-MRI or ultrasound, to generate patient-specific BCs for CFD models. It is then possible to elucidate, on a case-by-case basis, the highly individualized hemodynamics which occur due to geometric variations in aortic pathology high spatiotemporal resolution through CFD.
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影响因子：
4.6
作者：
Cherry, Molly;Khatir, Zinedine;Khan, Amirul;Bissell, Malenka
通讯作者：
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Chen D;Müller-Eschner M;von Tengg-Kobligk H;Barber D;Böckler D;Hose R;Ventikos Y
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2.2
作者：
Bonfanti, Mirko;Franzetti, Gaia;Diaz-Zuccarini, Vanessa
通讯作者：
Diaz-Zuccarini, Vanessa
影响因子：
3.7
作者：
Amaya R;Cancel LM;Tarbell JM
通讯作者：
Tarbell JM