Vascular Stem/Progenitor Cells in Vessel Injury and Repair.
Vascular Stem/Progenitor Cells in Vessel Injury and Repair.
复制标题
血管损伤和修复中的血管干/祖细胞。
DOI：
10.3389/fcvm.2022.845070
复制
发表时间：
2022
影响因子：
3.6
通讯作者：
Qu A
中科院分区：
文献类型：
--
作者：
Tao J;Cao X;Yu B;Qu A
血管损伤后的血管修复对于维持动脉的稳态和功能是必不可少的。干/祖细胞在血管修复过程中对受损血管细胞的再生和补充起着至关重要的作用。以往的研究表明，骨髓干/祖细胞是血管损伤后组织再生的主要来源。然而，不断发展的谱系追踪研究表明，不同的血管驻留干/祖细胞群体在不同的血管损伤和修复过程中发挥特定的作用。在响应剪切应力、炎症或其他危险因素诱导的血管损伤时，这些血管干/祖细胞可以被激活并因此分化成不同类型的血管壁细胞以参与血管修复。在这篇综述中，描述了有助于干细胞/祖细胞分化和血管修复的机制。靶向这些机制有可能改善以血管损伤为特征的疾病的结局，例如动脉粥样硬化、高血压、再狭窄和主动脉瘤/夹层。还强调了未来对潜在的干细胞治疗的研究。
Vascular repair upon vessel injury is essential for the maintenance of arterial homeostasis and function. Stem/progenitor cells were demonstrated to play a crucial role in regeneration and replenishment of damaged vascular cells during vascular repair. Previous studies revealed that myeloid stem/progenitor cells were the main sources of tissue regeneration after vascular injury. However, accumulating evidences from developing lineage tracing studies indicate that various populations of vessel-resident stem/progenitor cells play specific roles in different process of vessel injury and repair. In response to shear stress, inflammation, or other risk factors-induced vascular injury, these vascular stem/progenitor cells can be activated and consequently differentiate into different types of vascular wall cells to participate in vascular repair. In this review, mechanisms that contribute to stem/progenitor cell differentiation and vascular repair are described. Targeting these mechanisms has potential to improve outcome of diseases that are characterized by vascular injury, such as atherosclerosis, hypertension, restenosis, and aortic aneurysm/dissection. Future studies on potential stem cell-based therapy are also highlighted.
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影响因子：
7.5
作者：
Ciavarella C;Gallitto E;Ricci F;Buzzi M;Stella A;Pasquinelli G
通讯作者：
Pasquinelli G
影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
3.3
作者：
Ding, Dah-Ching;Shyu, Woei-Cherng;Lin, Shinn-Zong
通讯作者：
Lin, Shinn-Zong
DOI：
10.1164/rccm.201709-1835oc
发表时间：
2018-09-15
影响因子：
24.7
作者：
Dai, Zhiyu;Zhu, Maggie M.;Zhao, You-Yang
通讯作者：
Zhao, You-Yang
DOI：
10.1073/pnas.0907622106
发表时间：
2009-09-15
影响因子：
11.1
作者：
Bearzi, Claudia;Leri, Annarosa;Anversa, Piero
通讯作者：
Anversa, Piero