Alterations of Systemic and Hepatic Metabolic Function Following Exposure to Trans-nonachlor in Low and High Fat Diet Fed Male Sprague Dawley Rats.
Alterations of Systemic and Hepatic Metabolic Function Following Exposure to Trans-nonachlor in Low and High Fat Diet Fed Male Sprague Dawley Rats.
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DOI：
10.1177/10915818231170527
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发表时间：
2023-09
影响因子：
2.2
通讯作者：
Howell III, George E. E.
中科院分区：
文献类型：
--
作者：
McDevitt, Erin;Henein, Lucie;Crawford, Anna;Kondakala, Sandeep;Young, Darian;Meek, Edward;Howell III, George E. E.
在美国和世界范围内，代谢性疾病（如2型糖尿病（T2 D）和相关合并症）的总体患病率以惊人的速度增加。越来越多的流行病学证据表明，接触持久性有机污染物（POP），包括遗留的有机氯农药（OC）及其生物累积代谢物，是代谢性疾病的发病机制。因此，本研究的目的是确定是否暴露于transnonachlor，一种生物累积的OC农药污染物，在演唱会与高脂肪饮食摄入诱导代谢功能障碍。简言之，雄性Sprague道利大鼠在16周内接触低脂肪（LFD）或高脂肪饮食（HFD）中的反式九甲草胺（0.5或5 ppm）。在摄入8周时，反式九草胺降低了LFD和HFD喂养动物的血清甘油三酯水平，并在16周时与LFD喂养动物相比降低了血清甘油三酯水平。有趣的是，在16周时，反式-九甲草胺（5 ppm）降低了LFD喂养动物的血清葡萄糖水平。在16周时，LFD喂养动物的血清游离脂肪酸因反式九甲草胺暴露（5 ppm）而增加。喂食HFD的动物显示出肝脂肪变性的迹象，包括肝甘油三酯、肝酶和肝脂质过氧化升高，这些均未因接触反式九甲草胺而发生显著改变。然而，有一个反式-九甲草胺介导的脂肪酸合成酶在LFD喂养的动物，而不是HFD喂养的动物的肝脏中的表达增加。因此，目前的数据表明，接触反式九甲草胺与LFD或HFD摄入量一起对脂质和葡萄糖代谢产生饮食和接触依赖性影响。
The overall prevalence of metabolic diseases such as type 2 diabetes (T2D) and associated co-morbidities have increased at an alarming rate in the United States and worldwide. There is a growing body of epidemiological evidence implicating exposure to persistent organic pollutants (POPs), including legacy organochlorine (OC) pesticides and their bioaccumulative metabolites, in the pathogenesis of metabolic diseases. Therefore, the goal of the present study was to determine if exposure to transnonachlor, a bioaccumulative OC pesticide contaminant, in concert with high fat diet intake induced metabolic dysfunction. Briefly, male Sprague Dawley rats were exposed to trans-nonachlor (.5 or 5 ppm) in either a low fat (LFD) or high fat diet (HFD) for 16 weeks. At 8 weeks of intake, trans-nonachlor decreased serum triglyceride levels in LFD and HFD fed animals and at 16 weeks compared to LFD fed animals. Interestingly, serum glucose levels were decreased by trans-nonachlor (5 ppm) in LFD fed animals at 16 weeks. Serum free fatty acids were increased by trans-nonachlor exposure (5 ppm) in LFD fed animals at 16 weeks. HFD fed animals displayed signs of hepatic steatosis including elevated liver triglycerides, liver enzymes, and liver lipid peroxidation which were not significantly altered by trans-nonachlor exposure. However, there was a trans-nonachlor mediated increase in expression of fatty acid synthase in livers of LFD fed animals and not HFD fed animals. Thus, the present data indicate exposure to trans-nonachlor in conjunction with LFD or HFD intake produces both diet and exposure dependent effects on lipid and glucose metabolism.
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影响因子：
5.3
作者：
Honkakoski, P;Zelko, I;Negishi, M
通讯作者：
Negishi, M
影响因子：
7.7
作者：
Marchesini, G;Brizi, M;Melchionda, N
通讯作者：
Melchionda, N
影响因子：
4.5
作者：
Howell GE 3rd;McDevitt E;Henein L;Mulligan C;Young D
通讯作者：
Young D
影响因子：
4
作者：
Bowe, James E.;Franklin, Zara J.;Jones, Peter M.
通讯作者：
Jones, Peter M.
DOI：
10.1016/0306-3623(83)90028-9
发表时间：
1983-01-01
期刊：
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
影响因子：
--
作者：
CAMPBELL, MA;GYORKOS, J;SAFE, S
通讯作者：
SAFE, S