Senescence alters blood flow responses to acute heat stress.
Senescence alters blood flow responses to acute heat stress.
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衰老改变了血流对急性热应激的反应。
DOI：
10.1152/ajpheart.00857.2003
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Musch,TimothyI
中科院分区：
文献类型：
--
作者：
Kenney,MichaelJ;Musch,TimothyI
Renal and splanchnic sympathetic nerve discharge (SND) responses to heating are significantly reduced in senescent compared with young Fischer-344 (F344) rats (Kenney MJ and Fels RJ.Am J Physiol Regul Integr Comp Physiol283: R513–R520, 2002). However, the functional significance of this finding is not known. We tested the hypothesis that blood flow distribution profiles to heating are altered in senescent (24 mo old) compared with mature (12 mo old) and young (3 mo old) F344 rats. Visceral organ, skeletal muscle, and tail blood flows were determined with the radionuclide-tagged microsphere technique before (control, 38°C) and during heating that increased body temperature to 41°C in anesthetized F344 rats. Vascular conductance in the kidney, stomach, large intestine, pancreas, spleen, and tail was significantly reduced during control before heating in senescent compared with young F344 rats. Heating significantly decreased kidney, stomach, small and large intestine, and pancreas vascular conductance in young and mature but not senescent F344 rats. Vascular conductance at 41°C in the kidney and small intestine was significantly lower and in the stomach tended to be lower in young compared with senescent rats. Splenic conductance increased during heating in young and senescent rats but was highest in young rats. Tail conductance during heating was significantly increased in young rats but remained unchanged in mature and senescent rats. These results demonstrate a marked attenuation in heating-induced vascular conductance changes in senescent rats, suggesting an important functional consequence for the attenuated SND responses to heating in aged rats.
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影响因子：
3.3
作者：
Minson, CT;Wladkowski, SL;Kenney, WL
通讯作者：
Kenney, WL
DOI：
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发表时间：
1989
期刊：
影响因子：
--
作者：
M. Petrović;A. Suchocki;R. Powell;G. Cantwell;J. Aldridge
通讯作者：
J. Aldridge
腹腔神经节切除术或肾上腺脱髓术后对热的循环反应。
DOI：
10.1152/jappl.1989.66.3.1359
发表时间：
1989
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Kregel,KC;Gisolfi,CV
通讯作者：
Gisolfi,CV
一氧化氮相关机制在衰老大鼠肾功能中的作用。
DOI：
10.1093/ndt/13.3.594
发表时间：
1998
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
D. Tan;M. Cernadas;P. Aragoncillo;M. A. Castilla;M. V. Alvarez Arroyo;A. L. López Farré;S. Casado;C. Caramelo
通讯作者：
C. Caramelo
热应激和衰老对压力反射敏感性和血压频谱功率的调节。
DOI：
10.1152/ajpheart.1997.272.2.h776
发表时间：
1997
期刊：
The American journal of physiology
影响因子：
--
作者：
Stauss,HM;Morgan,DA;Anderson,KE;Massett,MP;Kregel,KC
通讯作者：
Kregel,KC