Modulation of baroreflex sensitivity and spectral power of blood pressure by heat stress and aging.
Modulation of baroreflex sensitivity and spectral power of blood pressure by heat stress and aging.
复制标题
热应激和衰老对压力反射敏感性和血压频谱功率的调节。
DOI：
10.1152/ajpheart.1997.272.2.h776
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Kregel,KC
中科院分区：
文献类型：
--
作者：
Stauss,HM;Morgan,DA;Anderson,KE;Massett,MP;Kregel,KC
为了研究高温和衰老对压力感受器-心率反射敏感性（BRS）的影响，在清醒的成熟和衰老的Fischer 344大鼠的核心温度进行性升高期间记录心血管参数。根据血压和心搏间期的自发变化计算BRS。还测定了低频（LF，0.01-0.20 Hz）和中频（MF，0.2-0.5 Hz）血压功率。在这两个年龄组中，高温引起血压，肾阻力，LF增加，但没有变化，肾神经活动，而心动过速只观察到在老年大鼠。BRS增加（0.80 +/- 0.14 vs. 1.72 +/- 0.34 ms/mmHg，P < 0.05）和MF（3.10 +/- 0.55 vs. 7.81 +/- 1.89 mmHg 2，P < 0.05）BRS与MF之间正相关（r = 0.50，P < 0.01）。这些结果表明，LF，这增加了核心温度升高，可能是由热刺激调制。在成熟组中增强的BRS可能有助于高温时发生的血流动力学调整，而在衰老组中热应激期间BRS没有增加表明压力感受器反射调制随着年龄的增长而受损。成熟大鼠BRS和MF之间的正相关，以及肾交感神经活动的缺乏增加，表明MF可能反映了压力感受性反射环的传出交感部分对动脉血压的调节作用，而不仅仅是外周交感神经系统的活动。
To investigate the effects of hyperthermia and aging on baroreceptor-heart rate reflex sensitivity (BRS), cardiovascular parameters were recorded during a progressive rise in core temperature in conscious mature and senescent Fischer 344 rats. BRS was calculated from spontaneous changes in blood pressure and interbeat interval. Low- (LF, 0.01-0.20 Hz) and mid- (MF, 0.2-0.5 Hz) frequency blood pressure power were also determined. In both age groups, hyperthermia caused an increase in blood pressure, renal resistance, and LF but no changes in renal nerve activity, whereas a tachycardia was only observed in the older rats. Increases in BRS (0.80 +/- 0.14 vs. 1.72 +/- 0.34 ms/mmHg, P < 0.05) and MF (3.10 +/- 0.55 vs. 7.81 +/- 1.89 mmHg2, P < 0.05) and a positive correlation between BRS and MF (r = 0.50, P < 0.01) were observed with heating in mature but not senescent rats. These results indicate that LF, which increased with elevated core temperature, may be modulated by thermal stimuli. The augmented BRS in the mature group may contribute to the hemodynamic adjustments that occur with hyperthermia, whereas the lack of an increase in BRS during heat stress in the senescent group suggests that baroreceptor reflex modulation is impaired with aging. The positive correlation between BRS and MF in mature rats, together with the lack of an increase in renal sympathetic nerve activity, indicates that MF may reflect the modulating influence of the efferent sympathetic portion of the baroreceptor reflex loop on arterial blood pressure rather than merely the activity of the peripheral sympathetic nervous system.
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交感神经活动随着年龄的增长而增加。
影响因子：
--
作者：
G. Hajduczok;M. Chapleau;S. L. Johnson;F. Abboud
通讯作者：
F. Abboud
DOI：
10.1016/0165-1838(90)90132-3
发表时间：
1990-06-01
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
JAPUNDZIC, N;GRICHOIS, ML;ELGHOZI, JL
通讯作者：
ELGHOZI, JL
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
DOI：
10.1093/geronj/37.2.130
发表时间：
1982-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
YU, BP;MASORO, EJ;LYND, FT
通讯作者：
LYND, FT
分析动脉压力反射的新方法。
DOI：
--
发表时间：
1985
期刊：
Journal of Hypertension - Supplement
影响因子：
--
作者：
G. Bertinieri;M. Rienzo;Anita Cavallazzi;A. Ferrari;A. Pedotti;G. Mancia
通讯作者：
G. Mancia