Can intestinal microbiota be associated with non-intestinal cancers?
Can intestinal microbiota be associated with non-intestinal cancers?
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DOI：
10.1038/s41598-017-11644-9
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发表时间：
2017-10-05
影响因子：
4.6
通讯作者：
Roche B
中科院分区：
文献类型：
--
作者：
Jacqueline C;Brazier L;Faugère D;Renaud F;Thomas F;Roche B
虽然肠道微生物群在消化道癌症病因学中的作用越来越受到认可，但其对身体其他部位癌症发展的影响却很少研究。通过新一代测序，我们旨在确定肠道微生物群结构与果蝇幼虫眼盘肿瘤存在之间的关联。首先，我们观察到亲本对细菌群落多样性和结构的影响。其次，我们确定了癌症的细菌特征（在家族水平上）：癌性幼虫比没有发展肿瘤的个体具有显著较低的芽孢杆菌科相对丰度。因此，我们第一次证明了非消化道癌症，即，在大脑中，可能与肠道微生物群落的组成改变有关。最后，我们讨论了免疫系统在肠-脑轴概念中的潜在意义，以解释肠道微生物群对脑肿瘤的长期影响。我们还强调了我们的研究结果在脑癌治疗方面的潜力，可以推广到其他癌症。
While the role of intestinal microbiota is increasingly recognized in the etiology of digestive cancers, its effects on the development of cancer in other parts of the body have been little studied. Through new-generation sequencing, we aimed to identify an association between the structure of intestinal microbiota and the presence of eye disc tumor in Drosophila larvae. First, we observed a parental effect on the diversity and structure of bacterial communities. Second, we identified a bacterial signature (at the family level) of cancer: cancerous larvae host a significantly lower relative abundance of Bacillaceae than individuals that did not develop the tumor. Thus, for the first time, we showed that a non-digestive cancer, i.e., in the brain, could be associated with an altered composition of the gut microbial community. Finally, we discuss the potential implications of the immune system in the gut–brain axis concept to explain the long-distant effect of intestinal microbiota on brain tumors. We also highlight the potential of our results in a therapeutic perspective for brain cancer that could be generalized for other cancers.
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影响因子：
4
作者：
Alcock, Joe;Maley, Carlo C.;Aktipis, C. Athena
通讯作者：
Aktipis, C. Athena
DOI：
10.1038/nrc1299
发表时间：
2004-03
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
16.6
作者：
Jangi S;Gandhi R;Cox LM;Li N;von Glehn F;Yan R;Patel B;Mazzola MA;Liu S;Glanz BL;Cook S;Tankou S;Stuart F;Melo K;Nejad P;Smith K;Topçuolu BD;Holden J;Kivisäkk P;Chitnis T;De Jager PL;Quintana FJ;Gerber GK;Bry L;Weiner HL
通讯作者：
Weiner HL
DOI：
10.1152/ajpgi.00029.2015
发表时间：
2015-05-15
影响因子：
4.5
作者：
Hamilton, M. Kristina;Boudry, Galle;Raybould, Helen E.
通讯作者：
Raybould, Helen E.
影响因子：
64.8
作者：
Grivennikov, Sergei I.;Wang, Kepeng;Mucida, Daniel;Stewart, C. Andrew;Schnabl, Bernd;Jauch, Dominik;Taniguchi, Koji;Yu, Guann-Yi;Oesterreicher, Christoph H.;Hung, Kenneth E.;Datz, Christian;Feng, Ying;Fearon, Eric R.;Oukka, Mohamed;Tessarollo, Lino;Coppola, Vincenzo;Yarovinsky, Felix;Cheroutre, Hilde;Eckmann, Lars;Trinchieri, Giorgio;Karin, Michael
通讯作者：
Karin, Michael