Oxidative stress and cerebral endothelial cells: regulation of the blood-brain-barrier and antioxidant based interventions.
Oxidative stress and cerebral endothelial cells: regulation of the blood-brain-barrier and antioxidant based interventions.
复制标题
氧化应激和脑内皮细胞：调节血脑屏障和基于抗氧化剂的干预措施。
DOI：
10.1016/j.bbadis.2011.12.009
复制
发表时间：
2012-05
影响因子：
6.2
通讯作者：
Keller, Jeffrey N.
中科院分区：
文献类型：
--
作者：
Freeman, Linnea R.;Keller, Jeffrey N.
关键词：
虽然大量证据表明氧化应激水平的增加在许多神经退行性疾病中起着因果作用，但我们目前对氧化应激在神经退行性疾病的发生和/或传播中的具体作用的理解仍然不明确。对“神经退行性变的氧化应激理论”更具挑战性的是，许多基于抗氧化剂的临床试验和治疗干预措施的治疗效果在很大程度上令人失望。这些因素共同促使研究人员开始关注大脑内高度局部化的结构的贡献，并定义了解剖学特征，作为氧化应激诱导的神经变性的部位。本综述重点关注脑血管结构内氧化应激在各种病理环境中作为神经变性调节剂的潜力。特别是，这篇综述强调了血管源性氧化应激在启动和促进大脑病理生理学中的重要意义，确定了脑血管氧化应激在各种脑部疾病中的新作用。
While numerous lines of evidence point to increased levels of oxidative stress playing a causal role in a number of neurodegenerative conditions, our current understanding of the specific role of oxidative stress in the genesis and/or propagation of neurodegenerative diseases remains poorly defined. Even more challenging to the “oxidative stress theory of neurodegeneration” is the fact that many antioxidant-based clinical trials and therapeutic interventions have been largely disappointing in their therapeutic benefit. Together, these factors have led researchers to begin to focus on understanding the contribution of highly localized structures, and defined anatomical features, within the brain as the sites responsible for oxidative stress-induced neurodegeneration. This review focuses on the potential for oxidative stress within the cerebrovascular architecture serving as a modulator of neurodegeneration in a variety of pathological settings. In particular, this review highlights important implications for vascular-derived oxidative stress in the initiating and promoting pathophysiology in the brain, identifying new roles for cerebrovascular oxidative stress in a variety of brain disorders.
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DOI：
10.1016/j.bbalip.2010.02.005
发表时间：
2010-08
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Butterfield DA;Bader Lange ML;Sultana R
通讯作者：
Sultana R
影响因子：
7.4
作者：
Bruce-Keller, Annadora J.;White, Christy L.;Gupta, Sunita;Knight, Alecia G.;Pistell, Paul J.;Ingram, Donald K.;Morrison, Christopher D.;Keller, Jeffrey N.
通讯作者：
Keller, Jeffrey N.
影响因子：
5.5
作者：
Basuroy, Shyamali;Bhattacharya, Sujoy;Parfenova, Helena
通讯作者：
Parfenova, Helena
影响因子：
6.6
作者：
Bruce-Keller, Annadora J.;Gupta, Sunita;Markesbery, William R.
通讯作者：
Markesbery, William R.
影响因子：
9.9
作者：
Dávalos, A;Castillo, J;Rama, R
通讯作者：
Rama, R