Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease.
Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease.
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DOI：
10.1016/j.bbalip.2010.02.005
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Sultana R
中科院分区：
文献类型：
--
作者：
Butterfield DA;Bader Lange ML;Sultana R
阿尔茨海默病（AD）是一种与年龄相关的神经退行性疾病。已经提出了许多假说来解释AD的发病机制。提出来解释AD发病机制的一个这样的假说是氧化应激假说。在AD受试者的脑中发现氧化应激标志物的水平增加，包括脂质过氧化的标志物，例如丙烯醛、4-羟基-2-反式壬烯醛（HNE）、丙二醛等。在这篇综述中，我们主要集中在该地区进行的研究HNE在中枢神经系统（CNS）的AD和轻度认知功能障碍（MCI），并进一步讨论可能的后果，脂质过氧化与AD的发病机制和进展。基于迄今为止在脂质过氧化领域进行的研究，表明脂质可及的抗氧化分子可能是治疗或减缓MCI和AD进展的有前景的治疗方法。
Alzheimer’s disease (AD) is an age-related neurodegenerative disorder. A number of hypotheses have been proposed to explain AD pathogenesis. One such hypothesis proposed to explain AD pathogenesis is the oxidative stress hypothesis. Increased levels of oxidative stress markers including the markers of lipid peroxidation such as acrolein, 4-hydroxy-2-trans-nonenal (HNE), malondialdehyde, etc. are found in brains of AD subjects. In this review we focus principally on research conducted in the area of HNE in the central nervous system (CNS) of AD and mild cognitive impairment (MCI), and further we discuss likely consequences of lipid peroxidation with respect to AD pathogenesis and progression. Based on the research conducted so far in the area of lipid peroxidation, it is suggested that lipid accessible antioxidant molecules could be a promising therapeutic approach to treat or slow progression of MCI and AD.
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影响因子：
2.5
作者：
Butterfield, DA;Reed, T;Sultana, R
通讯作者：
Sultana, R
DOI：
10.1016/j.bbadis.2004.12.002
发表时间：
2005-06-30
影响因子：
6.2
作者：
Abdul, HM;Butterfield, DA
通讯作者：
Butterfield, DA
影响因子：
5.3
作者：
Cenini G;Sultana R;Memo M;Butterfield DA
通讯作者：
Butterfield DA
影响因子：
6
作者：
Battino, M;Bompadre, S;Villa, RF
通讯作者：
Villa, RF
影响因子：
7.4
作者：
Castegna, A;Aksenov, M;Butterfield, DA
通讯作者：
Butterfield, DA