A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder.
A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder.
复制标题
一项针对患有自闭症和强迫症的成人重复性思想和行为的病例对照研究。
DOI：
10.1176/ajp.152.5.772
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Price,LH
中科院分区：
文献类型：
--
作者：
McDougle,CJ;Kresch,LE;Goodman,WK;Naylor,ST;Volkmar,FR;Cohen,DJ;Price,LH
目的本研究的目的是调查患有自闭症的成人所表现出的重复性思想和行为的类型，并将其与年龄和性别匹配的强迫症成人进行比较。方法连续 50 名入院于耶鲁大学成人广泛性发育障碍（自闭症）诊所且初步诊断为自闭症（DSM-III-R 和 DSM-IV）的患者完成了耶鲁-布朗强迫症症状检查表强迫量表。对当前的强迫观念和强迫行为的类型进行了评估。对照组由 50 名年龄和性别匹配的强迫症（无抽动）成人（DSM-III-R 和 DSM-IV）组成。结果直接判别函数分析显示，可以根据自闭症患者当前表现出的重复思想和行为的类型来区分自闭症患者和强迫症患者。与强迫症组相比，自闭症患者出现攻击性、污染、性、宗教、对称和躯体内容的想法的可能性显着降低。重复订购；囤积；讲述或询问（趋势）；触摸、敲击或摩擦；自闭症患者的自残或自残行为发生的频率明显更高，而清洁、检查和计数行为在自闭症患者中的发生率低于强迫症患者。此外，从耶鲁-布朗强迫量表症状检查表中确定了七个强迫变量的特定子集，可以可靠地预测自闭症组的成员资格。结论这些结果表明，自闭症的重复思想和行为特征与强迫症患者表现出的强迫症状显着不同。未来的研究有必要评估自闭症和强迫症患者的治疗反应以及重复思想和行为的神经生物学基础。
ObjectiveThe purpose of this study was to investigate the types of repetitive thoughts and behavior demonstrated by adults with autistic disorder and compare them with those of age-and sex-matched adults with obsessive-compulsive disorder.MethodFifty consecutive patients admitted to the Yale Adult Pervasive Developmental Disorders (Autism) Clinic with a primary diagnosis of autistic disorder (DSM-III-R and DSM-IV) completed the symptom checklist of the Yale-Brown Obsessive Compulsive Scale. Types of current obsessions and compulsions were evaluated. The comparison group consisted of 50 age-and sex-matched adults with obsessive-compulsive disorder (without tics)(DSM-III-R and DSM-IV).ResultsDirect discriminant function analysis showed that the patients with autistic disorder could be distinguished from those with obsessive-compulsive disorder on the basis of the types of current repetitive thoughts and behavior that they demonstrated. Compared to the obsessive-compulsive group, the autistic patients were significantly less likely to experience thoughts with aggressive, contamination, sexual, religious, symmetry, and somatic content. Repetitive ordering; hoarding; telling or asking (trend); touching, tapping, or rubbing; and self-damaging or self-mutilating behavior occurred significantly more frequently in the autistic patients, whereas cleaning, checking, and counting behavior was less common in the autistic group than in the patients with obsessive-compulsive disorder. In addition, a specific subset of seven obsessive-compulsive variables from the Yale-Brown Obsessive Compulsive Scale symptom checklist was identified that reliably predicted membership in the autistic group.ConclusionsThese results suggest that the repetitive thoughts and behavior characteristics of autism differ significantly from the obsessive-compulsive symptoms displayed by patients with obsessive-compulsive disorder. Future studies are warranted to assess the treatment response and neurobiological underpinnings of repetitive thoughts and behavior in patients with autism and obsessive-compulsive disorder.
登录
查看更多内容
DOI：
10.1176/ajp.138.12.1545
发表时间：
1992
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
J. Rapoport;S. Swedo;H. Leonard
通讯作者：
H. Leonard
影响因子：
10.5
作者：
P. Lindley;I. Marks;R. Philpott;J. Snowden
通讯作者：
J. Snowden
影响因子：
--
作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;Roberta L. Fleischmann;Candy L. Hill;G. Heninger;D. Charne
通讯作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;Roberta L. Fleischmann;Candy L. Hill;G. Heninger;D. Charne
依从性、“消极主义”以及自闭症治疗结构的影响：一项自然主义行为研究。
DOI：
10.1111/j.1469-7610.1985.tb00603.x
发表时间：
1985
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Volkmar,FR;Hoder,EL;Cohen,DJ
通讯作者：
Cohen,DJ
影响因子：
--
作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;P. Delgado;G. Heninger;D. Charney
通讯作者：
W. Goodman;L. Price;S. Rasmussen;C. Mazure;P. Delgado;G. Heninger;D. Charney