Selenorhodamine photosensitizers for photodynamic therapy of P-glycoprotein-expressing cancer cells.
Selenorhodamine photosensitizers for photodynamic therapy of P-glycoprotein-expressing cancer cells.
复制标题
DOI：
10.1021/jm501259v
复制
发表时间：
2014-10-23
影响因子：
7.3
通讯作者：
Detty MR
中科院分区：
文献类型：
--
作者：
Hill JE;Linder MK;Davies KS;Sawada GA;Morgan J;Ohulchanskyy TY;Detty MR
We examined a series of selenorhodamines with amide and thioamide functionality at the 5-position of a 9-(2-thienyl) substituent on the selenorhodamine core for their potential as photosensitizers for photodynamic therapy (PDT) in P-glycoprotein (P-gp) expressing cells. These compounds were examined for their photophysical properties (absorption, fluorescence, and ability to generate singlet oxygen), for their uptake into Colo-26 cells in the absence or presence of verapamil, for their dark and phototoxicity toward Colo-26 cells, for their rates of transport in monolayers of multidrug-resistant, P-gp-overexpressing MDCKII-MDR1 cells, and for their colocalization with mitochondrial specific agents in Colo-26 cells. Thioamide derivatives 16b and 18b were more effective photosensitizers than amide derivatives 15b and 17b. Selenorhodamine thioamides 16b and 18b were useful in a combination therapy to treat Colo-26 cells in vitro: a synergistic therapeutic effect was observed when Colo-26 cells were exposed to PDT and treatment with the cancer drug doxorubicin.
登录
查看更多内容
影响因子：
7.3
作者：
Gannon MK 2nd;Holt JJ;Bennett SM;Wetzel BR;Loo TW;Bartlett MC;Clarke DM;Sawada GA;Higgins JW;Tombline G;Raub TJ;Detty MR
通讯作者：
Detty MR
影响因子：
8.8
作者：
KESSEL, D;WOODBURN, K
通讯作者：
WOODBURN, K
影响因子：
4.8
作者：
Houghton, Peter;Fang, Rui;Lee, C. C.
通讯作者：
Lee, C. C.
影响因子：
3.6
作者：
BEAK, P;BROWN, RA
通讯作者：
BROWN, RA
影响因子：
2.8
作者：
Calitree, Brandon;Donnelly, David J.;Detty, Michael R.
通讯作者：
Detty, Michael R.