Prophylactic Indomethacin in extremely preterm infants: association with death or BPD and observed early serum creatinine levels.
Prophylactic Indomethacin in extremely preterm infants: association with death or BPD and observed early serum creatinine levels.
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DOI：
10.1038/s41372-021-00995-x
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Slaughter JL
中科院分区：
文献类型：
--
作者：
Abdi HH;Backes CH;Ball MK;Talavera-Barber MM;Klebanoff MA;Jadcherla SR;Mohamed TH;Slaughter JL
确定预防性吲哚美辛（PI）给药与1）经后36周龄（PMA）时死亡率和支气管肺发育不良（BPD）（主要结局）之间的关系，以及2）评价PI相关的急性肾损伤。对2009年5月至2017年9月期间出生后第0-1天在全国儿童医院住院且出生后存活≥24小时的22-28周妊娠婴儿（N= 1，167）进行回顾性队列研究。PI治疗与死亡率或BPD以及其他次要结局的相关性通过多变量稳健误差方差Poisson回归进行评估。多变量调整后，PI治疗后，36周PMA的死亡或BPD（1.02，95% CI：0.83，1.25）、BPD（0.97，95% CI：0.77，1.21）和死亡1.33（95% CI：0.84，2.10）的调整风险未发生变化。在暴露与未暴露的婴儿中未检测到平均肌酐水平的变化，表明PI诱导的阿基。预防性吲哚美辛治疗与死亡率或BPD结局无关。
To identify the relationship between prophylactic indomethacin (PI) administration and 1) mortality and bronchopulmonary dysplasia (BPD) at 36-weeks postmenstrual age (PMA) (primary outcome), and 2) to evaluate for PI-associated acute kidney injury. Retrospective cohort investigation of 22–28 weeks gestation infants (N=1,167) who were admitted to Nationwide Children’s Hospital on postnatal days 0–1 between May 2009-September 2017 and survived ≥24-hours postnatal. The associations of PI treatment with mortality or BPD, and other secondary outcomes, was evaluated via multivariable robust-error-variance Poisson regression. The adjusted risks of death or BPD (1.02, 95% CI: 0.83, 1.25), BPD (0.97, 95% CI: 0.77, 1.21), and death 1.33 (95% CI: 0.84, 2.10) by 36-weeks PMA were unchanged following PI treatment after multivariable adjustment. No changes in mean creatinine levels were detected in exposed versus unexposed infants to suggest PI-induced AKI. Prophylactic indomethacin treatment was unrelated to mortality or BPD outcomes.
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