Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study.
Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study.
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主观认知下降中的微结构和脑血流异常：扩散峰度成像和三维动脉自旋标记研究。
DOI：
10.3389/fnagi.2021.625843
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发表时间：
2021
影响因子：
4.8
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Yang Z;Rong Y;Cao Z;Wu Y;Zhao X;Xie Q;Luo M;Liu Y
目的：应用弥漫性峰度成像（DKI）和三维（3D）动脉自旋标记（ASL）技术探讨主观认知衰退加型（SCD加型）患者的显微结构和脑血流（CBF）异常。方法：招募27例SCD +患者、31例遗忘性轻度认知障碍（aMCI）患者和33例老年对照（ECs）患者，采用GE 3.0 t MRI行DKI和3D ASL。平均峰度（MK）、分数各向异性（FA）、平均扩散率（MD）和CBF值来自大脑的24个感兴趣区域（roi），包括双侧海马（Hip）亚区（头部、身体和尾部）、后扣带皮层（PCC）、楔前叶、丘脑背亚区（前核、腹侧核和内侧核）、晶面核、尾状核、额叶白质（WM）和枕叶WM。采用Pearson相关分析评估dki衍生参数、CBF值和SCD +的关键神经心理测试之间的关系。结果：与ECs相比，SCD +组患者的MK和CBF值明显下降，主要在髋关节和PCC， aMCI组患者的MK和CBF值比ECs和SCD +组患者在多个区域的异常更为明显。联合MK值对SCD +和ECs患者的区别优于CBF水平，受试者工作特征（ROC）曲线下面积（AUC）分别为0.874和0.837。同样，使用联合MK值区分SCD +和aMCI患者的AUC为0.823，也高于使用CBF值获得的联合AUC 0.779。此外，SCD +组左髋部(h)和左PCC的MK水平与听觉言语学习延迟回忆（AVLT-DR）得分呈正相关。相比之下，只有左髋头CBF值与AVLT-DR评分呈正相关。结论：我们的研究结果为SCD +患者的显微结构和CBF变化提供了新的证据。MK可以作为早期潜在的神经成像生物标志物，在阿尔茨海默病（AD）的早期阶段可能是比CBF更敏感的DKI参数。
Objective: To explore microstructural and cerebral blood flow (CBF) abnormalities in individuals with subjective cognitive decline plus (SCD plus) using diffusional kurtosis imaging (DKI) and three-dimensional (3D) arterial spin labeling (ASL). Methods: Twenty-seven patients with SCD plus, 31 patients with amnestic mild cognitive impairment (aMCI), and 33 elderly controls (ECs) were recruited and underwent DKI and 3D ASL using a GE 3.0-T MRI. Mean kurtosis (MK), fractional anisotropy (FA), mean diffusivity (MD), and CBF values were acquired from 24 regions of interest (ROIs) in the brain, including the bilateral hippocampal (Hip) subregions (head, body, and tail), posterior cingulate cortex (PCC), precuneus, dorsal thalamus subregions (anterior nucleus, ventrolateral nucleus, and medial nucleus), lenticular nucleus, caput nuclei caudati, white matter (WM) of the frontal lobe, and WM of the occipital lobe. Pearson's correlation analysis was performed to assess the relationships among the DKI-derived parameters, CBF values, and key neuropsychological tests for SCD plus. Results: Compared with ECs, participants with SCD plus showed a significant decline in MK and CBF values, mainly in the Hip head and PCC, and participants with aMCI exhibited more significant abnormalities in the MK and CBF values than individuals with ECs and SCD plus in multiple regions. Combined MK values showed better discrimination between patients with SCD plus and ECs than that obtained using CBF levels, with areas under the receiver operating characteristic (ROC) curve (AUC) of 0.874 and 0.837, respectively. Similarly, the AUC in discriminating SCD plus from aMCI patients obtained using combined MK values was 0.823, which was also higher than the combined AUC of 0.779 obtained using CBF values. Moreover, MK levels in the left Hip (h) and left PCC positively correlated with the auditory verbal learning test-delayed recall (AVLT-DR) score in participants with SCD plus. By contrast, only the CBF value in the left Hip head positively correlated with the AVLT-DR score. Conclusions: Our results provide new evidence of microstructural and CBF changes in patients with SCD plus. MK may be used as an early potential neuroimaging biomarker and may be a more sensitive DKI parameter than CBF at the very early stage of Alzheimer's disease (AD).
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影响因子：
4
作者：
Garcia de Eulate, Reyes;Goni, Irene;Fernandez-Seara, Maria A.
通讯作者：
Fernandez-Seara, Maria A.
DOI：
10.3233/jad-130011
发表时间：
2013
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Gordon BA;Blazey T;Benzinger TL;Head D
通讯作者：
Head D
影响因子：
2.5
作者：
Gong, Nan-Jie;Wong, Chun-Sing;Chu, Yiu-Ching
通讯作者：
Chu, Yiu-Ching
使用扩散率和峰度组合方法自动检测阿尔茨海默病的病理性白质改变
影响因子：
2.3
作者：
Chen, Yuanyuan;Sha, Miao;Ming, Dong
通讯作者：
Ming, Dong
影响因子：
11
作者：
Cappa, A;Calcagni, ML;Gainotti, G
通讯作者：
Gainotti, G