Expansion of the Clostridium perfringens toxin-based typing scheme.
Expansion of the Clostridium perfringens toxin-based typing scheme.
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DOI：
10.1016/j.anaerobe.2018.04.011
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发表时间：
2018-10
期刊：
影响因子：
2.3
通讯作者：
Van Immerseel F
中科院分区：
文献类型：
--
作者：
Rood JI;Adams V;Lacey J;Lyras D;McClane BA;Melville SB;Moore RJ;Popoff MR;Sarker MR;Songer JG;Uzal FA;Van Immerseel F
由于产气荚膜梭菌能够产生强效蛋白毒素，其中许多是细胞外的，因此在人类和动物中引起许多不同的组织毒性和肠毒性疾病。目前的分离物分类方案是在20世纪60年代完成的，基于它们产生α-毒素、β-毒素、ε-毒素和ι-毒素四种分型毒素的组合能力，将产气荚膜梭菌菌株分为a到e型毒素。然而，这种方案现在已经过时了，因为它没有考虑到其他毒素的发现，这些毒素已被证明是产气荚膜梭菌介导的特定疾病所必需的。我们提出了一项早该修订的毒素分型方案。本文描述了扩展分型系统的原则，以及提出并随后批准新毒素分型的机制。根据这些标准建立了两种新的毒素类型。F型产气荚膜荚膜菌由产生产气荚膜荚膜荚膜菌肠毒素（CPE）的分离株组成，但不产生β-毒素、ε-毒素或ι-毒素。F型菌株将包括导致产气荚膜梭菌介导的人类食物中毒和抗生素相关性腹泻的菌株。G型产气荚膜原包括产生NetB毒素并因此引起鸡坏死性肠炎的分离株。至少有两种候选的产气荚膜梭菌毒素类型，但在这些毒素类型被正式提出和接受之前，还需要进一步的实验工作。
Clostridium perfringens causes many different histotoxic and enterotoxic diseases in humans and animals as a result of its ability to produce potent protein toxins, many of which are extracellular. The current scheme for the classification of isolates was finalized in the 1960s and is based on their ability to produce a combination of four typing toxins - α-toxin, β-toxin, ε-toxin and ι-toxin – to divide C. perfringens strains into toxinotypes A to E. However, this scheme is now outdated since it does not take into account the discovery of other toxins that have been shown to be required for specific C. perfringens-mediated diseases. We present a long overdue revision of this toxinotyping scheme. The principles for the expansion of the typing system are described, as is a mechanism by which new toxinotypes can be proposed and subsequently approved. Based on these criteria two new toxinotypes have been established. C. perfringens type F consists of isolates that produce C. perfringens enterotoxin (CPE), but not β-toxin, ε-toxin or ι-toxin. Type F strains will include strains responsible for C. perfringens-mediated human food poisoning and antibiotic associated diarrhea. C. perfringens type G comprises isolates that produce NetB toxin and thereby cause necrotic enteritis in chickens. There are at least two candidates for future C. perfringens toxinotypes, but further experimental work is required before these toxinotypes can formally be proposed and accepted.
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影响因子：
2.2
作者：
Gohari, I. Mehdizadeh;Parreira, V. R.;Prescott, J. F.
通讯作者：
Prescott, J. F.
DOI：
10.1016/s0368-1742(38)80023-0
发表时间：
1938-01-01
期刊：
Journal of Comparative Pathology and Therapeutics
影响因子：
--
作者：
Dalltng, T.;Ross, H. E.
通讯作者：
Ross, H. E.
DOI：
10.1002/path.1700370107
发表时间：
1933-01-01
期刊：
JOURNAL OF PATHOLOGY AND BACTERIOLOGY
影响因子：
--
作者：
Glenny, AT;Barr, M;Ross, HE
通讯作者：
Ross, HE
影响因子：
2.3
作者：
Diniz, Amanda Nadia;Coura, Fernanda Morcatti;Silveira Silva, Rodrigo Otavio
通讯作者：
Silveira Silva, Rodrigo Otavio
影响因子：
6.4
作者：
Bannam TL;Yan XX;Harrison PF;Seemann T;Keyburn AL;Stubenrauch C;Weeramantri LH;Cheung JK;McClane BA;Boyce JD;Moore RJ;Rood JI
通讯作者：
Rood JI