Aquaporins as Prognostic Biomarker in Prostate Cancer.
Aquaporins as Prognostic Biomarker in Prostate Cancer.
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水通道蛋白作为前列腺癌预后的生物标志物。
作者：
水通道蛋白（Aquaporins，AQP）是一种跨膜通道蛋白，主要负责跨细胞膜转运水。已经发现AQP在包括前列腺癌在内的各种人类癌症中过表达。临床数据表明，水通道蛋白作为生物标志物的理想前景。这篇综述文章主要集中在水通道蛋白作为前列腺癌预后标志物的发展机会。前列腺癌是一种复杂的异质性疾病，影响全世界数百万男性。尽管在分子生物学和技术创新的快速进步，很少有生物标志物已在前列腺癌即将到来。目前可用于前列腺癌预后的生物标志物不足且面临挑战，因此具有有限的临床实用性。到目前为止，已经鉴定了许多前列腺癌的预后和预测生物标志物，但缺乏指导临床决策的特异性和敏感性。对于特定的生物标志物，仍然有巨大的空间来了解这种异质性疾病的自然史和复杂的生物学，并确定早期治疗反应。近年来的研究表明，水通道蛋白（AQP）家族可能作为前列腺癌的预后生物标志物监测疾病的进展。在本综述中，我们讨论了现有的前列腺癌生物标志物，它们的局限性，以及水通道蛋白作为前列腺癌预后意义的前瞻性生物标志物。
Aquaporins (AQPs) are transmembrane channel proteins that primarily transport water across the cellular membranes. AQPs have been found to be overexpressed in various human cancers, including prostate cancer. Clinical data suggest ideal prospects for AQPs as biomarkers. This review article mainly focuses on the opportunities for the development of AQPs as prognostic markers in prostate cancer. Prostate cancer is a complex heterogeneous disease that affects millions of males worldwide. Despite rapid advances in molecular biology and innovation in technology, few biomarkers have been forthcoming in prostate cancer. The currently available biomarkers for the prognosis of prostate cancer are inadequate and face challenges, thus having limited clinical utility. To date, there are a number of prognostic and predictive biomarkers identified for prostate cancer but lack specificity and sensitivity to guide clinical decision making. There is still tremendous scope for specific biomarkers to understand the natural history and complex biology of this heterogeneous disease, and to identify early treatment responses. Accumulative studies indicate that aquaporins (AQPs) a family of membrane water channels may serve as a prognostic biomarker for prostate cancer in monitoring disease advancement. In the present review, we discuss the existing prostate cancer biomarkers, their limitations, and aquaporins as a prospective biomarker of prognostic significance in prostate cancer.
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