Behavior of Monosodium Urate Crystals in a Highly Viscous Model of Synovial Fluid

Behavior of Monosodium Urate Crystals in a Highly Viscous Model of Synovial Fluid
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尿酸钠晶体在高粘性滑液模型中的行为

DOI:
10.1109/tmag.2019.2902443
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发表时间:
2019
影响因子:
2.1
通讯作者:
Matsuda Mizushi
Matsuda Mizushi
中科院分区:
工程技术4区
文献类型:
--
作者:
Takeuchi Yuka;Wada Yuta;Hamasaki Atom;Iwasaka Masakazu;Matsuda Mizushi

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为了开发利用磁场和近红外光诊断痛风的方法,对尿酸钠晶体在高粘度悬浮液中的取向行为进行了表征。透射光强度被用来监测电磁铁的定向时间和行为。在粘度为1250 mPa.S的甘油中,结晶在100mT的S温度为4500℃时择优取向。当磁场为500mT时,这被缩短到360 S。在透明质酸溶液中也观察到了类似的行为,透明质酸是滑液的一种成分,其粘度为960 mPa.S。当粘度小于或等于10 mPa.S时,结晶取向时间接近理论值,但在较高粘度时,结晶取向时间比预期的要短。一般来说,当关节出现炎症时,黏度下降到300mPa.S左右。在这种情况下,定位时间预计约为1分钟。在给定定位时间的情况下,设备应用是可能的。
To develop gout diagnosis using magnetic fields and near-infrared light, the orientation behavior of monosodium urate crystals in a highly viscous suspension was characterized. The transmitted light intensity was used to monitor orientation time and behavior within an electromagnet. In glycerol with a viscosity of 1250 mPa · s , the crystals were oriented in 4500 s at 100 mT. This was shortened to 360 s when the magnetic field was 500 mT. Similar behavior was observed in a hyaluronic acid solution, which is one component of synovial fluid and which had a viscosity of $960 mPa · s . The crystal orientation times followed theoretical values when the viscosity was $10 mPa · s or less but were shorter than expected at higher viscosities. In general, the viscosity decreases to about $300 mPa · s when inflammation occurs in a joint. In this case, the orientation time is expected to be about 1 min. Device applications are possible given the orientation times.
体内和体外尿酸盐晶体形成生物控制的形态学证据。
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