Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana.

Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana.
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DOI:
10.3201/eid1509.090224
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发表时间:
2009-09
影响因子:
11.8
通讯作者:
Drosten C
Drosten C
中科院分区:
医学2区
文献类型:
--
作者:
Pfefferle S;Oppong S;Drexler JF;Gloza-Rausch F;Ipsen A;Seebens A;Müller MA;Annan A;Vallo P;Adu-Sarkodie Y;Kruppa TF;Drosten C

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蹄蝠属蝙蝠携带一种冠状病毒,它与人类病毒有着共同的祖先。我们在加纳测试了12种蝙蝠的冠状病毒(CoV)RNA。食虫蝙蝠(n = 123)的病毒感染率为9.76%。在212份Eidolon helvum果蝠粪便样品中未检出CoV。叶鼻蝙蝠属于红蹄蝠的形态有组1和组2冠状病毒。病毒浓度<45,000拷贝/100毫克蝙蝠粪便。多样化的第1组CoV与人类普通感冒病毒hCoV-229 E共享共同的祖先,但与hCoV-NL 63不同,这对人类共同血统的假设提出了质疑。hCoV-229 E和GhanaBt-CoVGrp 1的最新共同祖先存在于公元1686-1800年。GhanaBt-CoVGrp 2与严重急性呼吸道综合征样CoV组有着共同的祖先(2,400年前)。
Hipposideros spp. bats harbor a coronavirus that shares common ancestry with human viruses. We tested 12 bat species in Ghana for coronavirus (CoV) RNA. The virus prevalence in insectivorous bats (n = 123) was 9.76%. CoV was not detected in 212 fecal samples from Eidolon helvum fruit bats. Leaf-nosed bats pertaining to Hipposideros ruber by morphology had group 1 and group 2 CoVs. Virus concentrations were <45,000 copies/100 mg of bat feces. The diversified group 1 CoV shared a common ancestor with the human common cold virus hCoV-229E but not with hCoV-NL63, disputing hypotheses of common human descent. The most recent common ancestor of hCoV-229E and GhanaBt-CoVGrp1 existed in ≈1686–1800 ad. The GhanaBt-CoVGrp2 shared an old ancestor (≈2,400 years) with the severe acute respiratory syndrome–like group of CoV.
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