Periodic limb movements in sleep: Prevalence and associated sleepiness in the Wisconsin Sleep Cohort.
Periodic limb movements in sleep: Prevalence and associated sleepiness in the Wisconsin Sleep Cohort.
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DOI：
10.1016/j.clinph.2018.08.022
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Mignot E
中科院分区：
文献类型：
--
作者：
Leary EB;Moore HE 4th;Schneider LD;Finn LA;Peppard PE;Mignot E
睡眠中的周期性肢体运动（PLMS）被认为在老年人中很普遍，但其对生活质量的影响尚不清楚。我们研究了PLMS的患病率、年龄对患病率的影响以及PLMS与嗜睡之间的关系。我们从12年来收集的2335张威斯康星州睡眠队列多导睡眠图中确定了肢体运动。在基线时计算周期性肢体运动指数(PLMI)≥15的患病率（n= 1,084）。McNemar的测试评估了患病率随时间的变化。利用线性混合模型和广义估计方程评估嗜睡与PLMS的关系。根据混杂因素调整模型。基线时PLMI≥15的患病率为25.3%。纵向患病率随着年龄的增长而显著增加（p=2.97 × 10−14）。睡意在PLMI组之间没有显著差异，除非根据不宁腿综合征（RLS）症状分层。RLS+/PLM+组较RLS+/PLM−组嗜睡。与RLS−/PLM−相比，RLS−/PLM+组的多次睡眠潜伏期测试倾向于提高警觉性。相当多的成年人患有PLMS，患病率随着年龄的增长而增加。PLMI类别与嗜睡之间无显著关联，除非根据RLS症状分层。我们的研究结果表明，RLS和PLMS可能有不同的临床结果和相互作用，可以帮助指导治疗方法。
Periodic limb movements in sleep (PLMS) are thought to be prevalent in elderly populations, but their impact on quality of life remains unclear. We examined the prevalence of PLMS, impact of age on prevalence, and association between PLMS and sleepiness. We identified limb movements in 2,335 Wisconsin Sleep Cohort polysomnograms collected over 12 years. Prevalence of periodic limb movement index (PLMI) ≥15 was calculated at baseline (n=l,084). McNemar's test assessed changes in prevalence over time. Association of sleepiness and PLMS evaluated using linear mixed modeling and generalized estimating equations. Models adjusted for confounders. Prevalence of PLMI ≥15 at baseline was 25.3%. Longitudinal prevalence increased significantly with age (p=2.97x10−14). Sleepiness did not differ significantly between PLMI groups unless stratified by restless legs syndrome (RLS) symptoms. The RLS+/PLM+ group was sleepier than the RLS+/PLM− group. Multiple Sleep Latency Test trended towards increased alertness in the RLS−/PLM+ group compared to RLS−/PLM−. A significant number of adults have PLMS and prevalence increased with age. No noteworthy association between PLMI category and sleepiness unless stratified by RLS symptoms. Our results indicate that RLS and PLMS may have distinct clinical consequences and interactions that can help guide treatment approach.
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DOI：
10.1093/geronj/40.4.419
发表时间：
1985-01-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
ANCOLIISRAEL, S;KRIPKE, DF;KAPLAN, OJ
通讯作者：
KAPLAN, OJ
影响因子：
4.3
作者：
Claman, David M.;Ewing, Susan K.;Stone, Katie L.
通讯作者：
Stone, Katie L.
影响因子：
4.8
作者：
Ferri, Raffaele;Manconi, Mauro;Zucconi, Marco
通讯作者：
Zucconi, Marco
影响因子：
4.4
作者：
Johns, MW
通讯作者：
Johns, MW
影响因子：
2.2
作者：
Orwoll, E;Blank, JB;Stone, K
通讯作者：
Stone, K