Designing spatial and temporal control of vaccine responses.
Designing spatial and temporal control of vaccine responses.
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DOI：
10.1038/s41578-021-00372-2
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Appel EA
中科院分区：
文献类型：
--
作者：
Roth GA;Picece VCTM;Ou BS;Luo W;Pulendran B;Appel EA
Vaccines are the key technology to combat existing and emerging infectious diseases. However, increasing the potency, quality and durability of the vaccine response remains a challenge. As our knowledge of the immune system deepens, it becomes clear that vaccine components must be in the right place at the right time to orchestrate a potent and durable response. Material platforms, such as nanoparticles, hydrogels and microneedles, can be engineered to spatially and temporally control the interactions of vaccine components with immune cells. Materials-based vaccination strategies can augment the immune response by improving innate immune cell activation, creating local inflammatory niches, targeting lymph node delivery and controlling the time frame of vaccine delivery, with the goal of inducing enhanced memory immunity to protect against future infections. In this Review, we highlight the biological mechanisms underlying strong humoral and cell-mediated immune responses and explore materials design strategies to manipulate and control these mechanisms. The immune response to a vaccine is characterized by a complex time-dependent interplay between various cell types and molecules in different tissues in our body. This Review explores materials-based strategies for the spatial and temporal control of the mechanisms that underlie vaccine immune responses.
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影响因子：
16.6
作者：
Appel EA;Tibbitt MW;Webber MJ;Mattix BA;Veiseh O;Langer R
通讯作者：
Langer R
影响因子：
16.1
作者：
Batty CJ;Heise MT;Bachelder EM;Ainslie KM
通讯作者：
Ainslie KM
影响因子：
19
作者：
Aubry, Taylor J.;Winchell, K. J.;Schwartz, Benjamin J.
通讯作者：
Schwartz, Benjamin J.
影响因子：
4.1
作者：
Apostólico Jde S;Lunardelli VA;Coirada FC;Boscardin SB;Rosa DS
通讯作者：
Rosa DS
影响因子：
168.9
作者：
Buchbinder, Susan P.;Mehrotra, Devon V.;Duerr, Ann;Fitzgerald, Daniel W.;Mogg, Robin;Li, David;Gilbert, Peter B.;Lama, Javier R.;Marmor, Michael;del Rio, Carlos;McElrath, M. Juliana;Casimiro, Danilo R.;Gottesdiener, Keith M.;Chodakewitz, Jeffrey A.;Corey, Lawrence;Robertson, Michael N.
通讯作者：
Robertson, Michael N.