Cell cycle regulation of proliferation versus differentiation in the central nervous system.
Cell cycle regulation of proliferation versus differentiation in the central nervous system.
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DOI：
10.1007/s00441-014-1895-8
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发表时间：
2015-01
影响因子：
3.6
通讯作者：
Philpott, Anna
中科院分区：
文献类型：
--
作者：
Hardwick, Laura J. A.;Ali, Fahad R.;Azzarelli, Roberta;Philpott, Anna
中枢神经系统的形成需要一段时期的祖细胞广泛增殖，并伴随或紧接着分化；中枢神经系统各个区域这两个过程之间的平衡导致了生长差异和细胞多样性。细胞周期延长和分化之间的相关性已在多种类型的细胞谱系和不同的模型生物体内和体外得到报道。此外，不同的细胞命运可能是在先前细胞周期的不同阶段决定的，表明细胞周期对早期谱系定型和终末细胞命运决定都有直接影响。过去十年取得了重大进展，揭示了调节细胞增殖和神经元分化过程的分子机制之间的多向相互作用。在这里，我们首先介绍神经祖细胞的增殖模式，并总结细胞周期长度和神经元分化之间联系的证据。其次，我们描述了细胞周期机制的组成部分在直接调节神经发生中发挥额外的、有时独立于细胞周期的作用的方式。最后，我们讨论了分化因子（例如原神经 bHLH 蛋白）如何根据细胞环境促进祖细胞维持或分化。这些错综复杂的联系有助于精确协调和最终的区分与分化决策。
Formation of the central nervous system requires a period of extensive progenitor cell proliferation, accompanied or closely followed by differentiation; the balance between these two processes in various regions of the central nervous system gives rise to differential growth and cellular diversity. The correlation between cell cycle lengthening and differentiation has been reported across several types of cell lineage and from diverse model organisms, both in vivo and in vitro. Furthermore, different cell fates might be determined during different phases of the preceding cell cycle, indicating direct cell cycle influences on both early lineage commitment and terminal cell fate decisions. Significant advances have been made in the last decade and have revealed multi-directional interactions between the molecular machinery regulating the processes of cell proliferation and neuronal differentiation. Here, we first introduce the modes of proliferation in neural progenitor cells and summarise evidence linking cell cycle length and neuronal differentiation. Second, we describe the manner in which components of the cell cycle machinery can have additional and, sometimes, cell-cycle-independent roles in directly regulating neurogenesis. Finally, we discuss the way that differentiation factors, such as proneural bHLH proteins, can promote either progenitor maintenance or differentiation according to the cellular environment. These intricate connections contribute to precise coordination and the ultimate division versus differentiation decision.
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影响因子：
4.8
作者：
Dobashi, Y;Shoji, M;Kameya, T
通讯作者：
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影响因子：
64.5
作者：
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5.3
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影响因子：
5.2
作者：
Caronna, Elizabeth A.;Patterson, Ethan S.;Hummert, Pamela M.;Kroll, Kristen L.
通讯作者：
Kroll, Kristen L.