A theranostic 3D ultrasound imaging system for high resolution image-guided therapy.
A theranostic 3D ultrasound imaging system for high resolution image-guided therapy.
复制标题
DOI：
10.7150/thno.71221
复制
发表时间：
2022
期刊：
影响因子：
12.4
通讯作者：
Ferrara, Katherine W.
中科院分区：
文献类型：
--
作者：
Bendjador, Hanna;Foiret, Josquin;Wodnicki, Robert;Stephens, Douglas N.;Krut, Zoe;Park, Eun-Yeong;Gazit, Zulma;Gazit, Dan;Pelled, Gadi;Ferrara, Katherine W.
微泡造影剂是一种诊断工具，具有广泛的临床影响和越来越多的适应症。许多治疗应用也已被确定。然而，超声引导微泡介导治疗的技术是有限的。特别是，能够在三维实时实现和成像微泡治疗的阵列是缺乏的。我们提出了一个系统来执行和监测基于微泡的治疗，能够在大视野内进行体积成像。为了推动治疗策略的发展，我们设计并测试了一种独特的阵列和系统，用于基于频率，时间和空间要求的基于微泡的3D超声引导治疗方案。方法：4台256通道平面波扫描仪（Verasonics, Inc， WA， USA）联合控制1024单元平面阵列，分别以1.3和2.5 MHz的治疗和成像传输。选取孔径为~40×15 mm的换能器，应用Field II计算点扩散函数。在商业和定制模型上进行了体外实验，以评估空间分辨率，图像对比度和微泡增强成像能力。结果：我们发现64个元素在方位角上以λ节距间隔，16个元素在仰角上以1.5λ节距间隔的二维阵列结构保证了所需的灵活性。该设计尺寸为41.6 mm × 16 mm，因此提供了一个扩展的视野，在10厘米深度下可达11厘米× 6厘米，方位角为±18°，仰角为±12°。在深度为16 cm的b模式下，我们实现了60 Hz的体积采集速率和30 Hz的成像显示速率。横向分辨率在5 cm深度为0.8 mm，在12.5 cm深度为2.1 mm。结论：用于成像和治疗的单一二维阵列，与1024通道扫描仪集成，可以在感兴趣的体积区域指导基于微泡的治疗。
Microbubble contrast agents are a diagnostic tool with broad clinical impact and an increasing number of indications. Many therapeutic applications have also been identified. Yet, technologies for ultrasound guidance of microbubble-mediated therapy are limited. In particular, arrays that are capable of implementing and imaging microbubble-based therapy in three dimensions in real-time are lacking. We propose a system to perform and monitor microbubble-based therapy, capable of volumetric imaging over a large field-of-view. To propel the promise of the theranostic treatment strategies forward, we have designed and tested a unique array and system for 3D ultrasound guidance of microbubble-based therapeutic protocols based on the frequency, temporal and spatial requirements. Methods: Four 256-channel plane wave scanners (Verasonics, Inc, WA, USA) were combined to control a 1024-element planar array with 1.3 and 2.5 MHz therapeutic and imaging transmissions, respectively. A transducer aperture of ~40×15 mm was selected and Field II was applied to evaluate the point spread function. In vitro experiments were performed on commercial and custom phantoms to assess the spatial resolution, image contrast and microbubble-enhanced imaging capabilities. Results: We found that a 2D array configuration with 64 elements separated by λ-pitch in azimuth and 16 elements separated by 1.5λ-pitch in elevation ensured the required flexibility. This design, of 41.6 mm × 16 mm, thus provided both an extended field-of-view, up to 11 cm x 6 cm at 10 cm depth and steering of ±18° in azimuth and ±12° in elevation. At a depth of 16 cm in B-mode, we achieved a volume acquisition rate of 60 Hz and an imaging display rate of 30 Hz. Lateral resolution was 0.8 mm at 5 cm depth and 2.1 mm at 12.5 cm depth. Conclusion: A single 2D array for both imaging and therapeutics, integrated with a 1024 channel scanner can guide microbubble-based therapy in volumetric regions of interest.
登录
查看更多内容
影响因子：
10.6
作者：
Arvanitis CD;Crake C;McDannold N;Clement GT
通讯作者：
Clement GT
影响因子：
2.4
作者：
JENSEN, JA
通讯作者：
JENSEN, JA
影响因子：
10.6
作者：
Bendjador, Hanna;Deffieux, Thomas;Tanter, Mickael
通讯作者：
Tanter, Mickael
影响因子：
10.6
作者：
Christensen-Jeffries, Kirsten;Browning, Richard J.;Eckersley, Robert J.
通讯作者：
Eckersley, Robert J.
影响因子：
5.7
作者：
Demene, Charlie;Tiran, Elodie;Tanter, Mickael
通讯作者：
Tanter, Mickael