Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes.
Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes.
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DOI:
10.1021/nl801362a
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发表时间:
2008-09
期刊:
影响因子:
10.8
通讯作者:
Gambhir SS
中科院分区:
文献类型:
--
作者:
Zavaleta C;de la Zerda A;Liu Z;Keren S;Cheng Z;Schipper M;Chen X;Dai H;Gambhir SS
An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor (p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.
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