Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes.

Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes.
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DOI:
10.1021/nl801362a
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发表时间:
2008-09
期刊:
影响因子:
10.8
通讯作者:
Gambhir SS
Gambhir SS
中科院分区:
材料科学1区
文献类型:
--
作者:
Zavaleta C;de la Zerda A;Liu Z;Keren S;Cheng Z;Schipper M;Chen X;Dai H;Gambhir SS

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利用优化的无创性拉曼显微镜对单壁碳纳米管(SWNTs)在小鼠体内的肿瘤靶向性和定位性进行了研究。在两组荷瘤小鼠中获得拉曼图像。对照组接受普通单壁碳纳米管,而实验组接受肿瘤靶向RGD-SWNTs静脉注射。拉曼成像在接下来的72小时内开始,并显示与普通SWNT相比,RGD-SWNT在肿瘤中的积累增加(p < 0.05)。这些结果支持一种新的临床前拉曼成像仪的发展。
An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor (p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.
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