Poor air quality in classrooms related to asthma and rhinitis in primary schoolchildren of the French 6 Cities Study.
Poor air quality in classrooms related to asthma and rhinitis in primary schoolchildren of the French 6 Cities Study.
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DOI：
10.1136/thoraxjnl-2011-200391
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发表时间：
2012-08
期刊：
影响因子：
10
通讯作者：
Denis C
中科院分区：
文献类型：
--
作者：
Annesi-Maesano I;Hulin M;Lavaud F;Raherison C;Kopferschmitt C;de Blay F;Charpin DA;Denis C
在学校发现的室内空气质量（IAQ）和学生的过敏和呼吸系统健康之间的关系还没有得到充分的探讨。在法国的小学教室中进行了一项大样本调查，以客观评估年幼学童在教室中暴露的室内空气质量，并将教室中发现的主要空气污染物与学童的哮喘和过敏症联系起来。在法国6个城市的研究中，在108所小学的401个随机选择的教室中客观地评估了空气动力学直径≤2.5 μm的细颗粒物（PM2.5）、二氧化氮（NO2）和三种醛类的浓度，这些教室有6590名儿童（平均年龄10.4岁，SD ±0.7）。该调查包括一次医疗访问，包括常见过敏原的皮肤点刺试验（SPT），筛查运动诱发性哮喘（EIA）的测试和由父母完成的标准化健康问卷。儿童在教室中暴露于空气质量差的情况各不相同，根据现有标准，近30%的儿童高度暴露于空气质量差的情况。在调整混杂因素后，过去一年的鼻结膜炎与教室中高水平的甲醛显著相关（OR 1.19; 95%CI 1.04至1.36）。此外，在PM2.5（OR 1.21; 95%CI 1.05 - 1.39）、丙烯醛（OR 1.22; 95%CI 1.09 - 1.38）和NO2（OR 1.16; 95%CI 0.95 - 1.41）水平较高的教室中，过去一年哮喘的患病率较高。观察到的关系主要是过敏性哮喘定义使用SPT。EIA与同周PM2.5和丙烯醛浓度呈显著正相关。在这个随机样本中，教室的空气质量很差，在学校和城市之间差异很大，并且与学童哮喘和鼻炎临床表现的患病率增加有关。有过敏背景的儿童似乎风险更高。
Relationships between indoor air quality (IAQ) found in schools and the allergic and respiratory health of schoolchildren have been insufficiently explored. A survey was conducted in a large sample of classrooms of primary schools in France to provide objective assessments of IAQ to which young schoolchildren are exposed in classrooms, and to relate exposure to major air pollutants found in classrooms to asthma and allergies of schoolchildren. Concentrations of fine particles with aerodynamic diameter ≤2.5 μm (PM2.5), nitrogen dioxide (NO2) and three aldehydes were objectively assessed in 401 randomly chosen classrooms in 108 primary schools attended by 6590 children (mean age 10.4 years, SD ±0.7) in the French 6 Cities Study. The survey incorporated a medical visit including skin prick testing (SPT) for common allergens, a test for screening exercise-induced asthma (EIA) and a standardised health questionnaire completed by parents. Children were differently exposed to poor air quality in classrooms, with almost 30% being highly exposed according to available standards. After adjusting for confounders, past year rhinoconjunctivitis was significantly associated with high levels of formaldehyde in classrooms (OR 1.19; 95% CI 1.04 to 1.36). Additionally, an increased prevalence of past year asthma was found in the classrooms with high levels of PM2.5 (OR 1.21; 95% CI 1.05 to 1.39), acrolein (OR 1.22; 95% CI 1.09 to 1.38) and NO2 (OR 1.16; 95% CI 0.95 to 1.41) compared with others. The relationship was observed mostly for allergic asthma as defined using SPT. A significant positive correlation was found between EIA and the levels of PM2.5 and acrolein in the same week. In this random sample, air quality in classrooms was poor, varied significantly among schools and cities, and was related to an increased prevalence of clinical manifestations of asthma and rhinitis in schoolchildren. Children with a background of allergies seemed at increased risk.
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影响因子：
6.1
作者：
Smedje, G;Norback, D;Edling, C
通讯作者：
Edling, C
DOI：
10.1513/pats.201001-004sm
发表时间：
2010-07-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Bessac, Bret F;Jordt, Sven-Eric
通讯作者：
Jordt, Sven-Eric
影响因子：
4.3
作者：
Annesi-Maesano, Isabella;Moreau, David;Charpin, Denis
通讯作者：
Charpin, Denis
影响因子：
2.6
作者：
Geller, Robert J.;Rubin, I. Leslie;Frumkin, Howard
通讯作者：
Frumkin, Howard
影响因子：
2.2
作者：
Tortolero, SR;Bartholomew, LK;Parcel, GS
通讯作者：
Parcel, GS