E-cadherin and alpha-, beta- and gamma-catenin expression in prostate cancers: correlation with tumour invasion.
E-cadherin and alpha-, beta- and gamma-catenin expression in prostate cancers: correlation with tumour invasion.
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DOI：
10.1038/sj.bjc.6690299
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发表时间：
1999-04
影响因子：
8.8
通讯作者：
Hiasa, Y
中科院分区：
文献类型：
--
作者：
Morita, N;Uemura, H;Tsumatani, K;Cho, M;Hirao, Y;Okajima, E;Konishi, N;Hiasa, Y
E-cadherin-catenin复合物在建立和维持细胞间连接和形态发生中起重要作用，其组成分子的表达减少与侵袭和转移有关。在本研究中，我们检测了根治性前列腺切除术获得的肿瘤组织中E-cadherin和α-， β-和γ-catenin的水平，以探讨其与组织病理学肿瘤侵袭的关系。45例前列腺癌标本的免疫组化结果显示，每种分子的异常表达与去分化有关，此外，三种catenin染色模式的改变与包膜浸润显著相关，而与淋巴或血管浸润无关。因此，这些数据表明，三种类型的连环蛋白可能是前列腺癌生物侵袭性的有用预测标志物。©1999癌症研究运动
The E-cadherin–catenin complex plays an important role in establishing and maintaining intercellular connections and morphogenesis and reduced expression of its constituent molecules is associated with invasion and metastasis. In the present study, we examined E-cadherin and α-, β- and γ-catenin levels in tumour tissues obtained by radical prostatectomy in order to investigate the relationship with histopathological tumour invasion. Immunohistochemical findings for 45 prostate cancer specimens demonstrated aberrant expression of each molecule to be associated with dedifferentiation and, in addition, alteration of staining patterns for the three types of catenin was significantly correlated with capsular but not lymphatic or vascular invasion. The data thus suggest that three types of catenin may be useful predictive markers for biological aggressiveness of prostate cancer. © 1999 Cancer Research Campaign
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影响因子：
56.9
作者：
TAKEICHI, M
通讯作者：
TAKEICHI, M
影响因子：
254.7
作者：
BORING, CC;SQUIRES, TS;TONG, T
通讯作者：
TONG, T
DOI：
10.1083/jcb.108.6.2435
发表时间：
1989-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Behrens J;Mareel MM;Van Roy FM;Birchmeier W
通讯作者：
Birchmeier W
影响因子：
64.5
作者：
NAGAFUCHI, A;TAKEICHI, M;TSUKITA, S
通讯作者：
TSUKITA, S
影响因子：
--
作者：
FOURNIER, G;LATIL, A;LIDEREAU, R
通讯作者：
LIDEREAU, R