Inflammatory Cell Numbers in the Stomach of Japanese Subjects with Endoscopically Normal Mucosa without <b><i>Helicobacter pylori</i></b> Infection
Inflammatory Cell Numbers in the Stomach of Japanese Subjects with Endoscopically Normal Mucosa without <b><i>Helicobacter pylori</i></b> Infection
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内镜下粘膜正常的日本受试者胃中炎症细胞数量
DOI：
10.1159/000515345
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发表时间：
2021
影响因子：
2.3
通讯作者：
Takao Toshihiro
中科院分区：
文献类型：
--
作者：
Sumi Naoki;Haruma Ken;Kamada Tomoari;Suehiro Mitsuhiko;Manabe Noriaki;Akiyama Takashi;Shiotani Akiko;Yamanaka Yoshiyuki;Fujimoto Sohachi;Takao Toshihiro
由于炎症细胞，如淋巴细胞和浆细胞，通常居住在胃，正常和轻度炎症之间的边界是很难用视觉上确定更新的悉尼系统胃炎量表。此外，胃粘膜中的嗜酸性粒细胞必须计数以诊断嗜酸性胃炎。我们的目的是确定内窥镜检查正常粘膜且无幽门螺杆菌感染的患者中炎症细胞的正常数量。方法我们评估了2010年1月至2014年12月期间在川崎医学院医院接受上消化道内窥镜检查的20-79岁患者。在幽门和胃底腺粘膜活检标本的1，000 μ m2视野中计数炎性细胞。我们最终纳入了325例（男性，n= 141;女性，n= 184;平均年龄= 49.3岁）患有H.结果幽门和胃底腺粘膜中有核细胞平均数分别为83.3±14.2和65.4±12.6个/mm 2。幽门黏膜炎性细胞明显多于胃底腺黏膜（p< 0.05）。年龄和性别分布没有显著差异。嗜酸性粒细胞在所有patients.ConclusionWe确定的绝对值的炎症细胞，包括嗜酸性粒细胞，在幽门和胃底腺的正常粘膜中的胃粘膜中均不存在或很少。这些发现在定义胃粘膜炎症，包括嗜酸性胃炎的诊断中可能是重要的。
IntroductionSince inflammatory cells, such as lymphocytes and plasma cells, normally inhabit the stomach, the border between normal and mild inflammation is difficult to visually determine using the updated Sydney system scale of gastritis. Additionally, eosinophils in the gastric mucosa must be counted to diagnose eosinophilic gastritis. We aimed to determine the normal number of inflammatory cells in patients with endoscopically normal mucosa and without Helicobacter pylori infections.MethodsWe assessed patients aged 20–79 years, who had undergone upper gastrointestinal endoscopy at Kawasaki Medical School Hospital between January 2010 and December 2014. Inflammatory cells were counted in 1,000 μm 2 fields of pyloric and fundic gland mucosal biopsy specimens. We finally included 325 (male, n= 141; female, n= 184; average age= 49.3 years) patients without inflammation who had H. pylori-negative endoscopic results and negative histological findings interpreted based on the updated Sydney System and the Kyoto classification of gastritis.ResultsThe average numbers of nucleated cells were 83.3±14.2 and 65.4±12.6/mm 2 in the pyloric and fundic gland mucosae, respectively. Inflammatory cells were significantly more abundant in the pyloric mucosa than in the fundic gland mucosa (p< 0.05). Age and sex distribution did not significantly differ. Eosinophils were absent or scanty in the gastric mucosae of both glands in all patients.ConclusionWe determined the absolute values of inflammatory cells, including eosinophils, in normal mucosae of pyloric and fundic glands. These findings could be important in defining gastric mucosal inflammation, including eosinophilic gastritis diagnosis.
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影响因子：
24.5
作者：
TALLEY, NJ;SHORTER, RG;ZINSMEISTER, AR
通讯作者：
ZINSMEISTER, AR
影响因子：
6.4
作者：
ANDREW, A;WYATT, JI;DIXON, MF
通讯作者：
DIXON, MF
36 例日本嗜酸粒细胞性食管炎患者的临床特征
DOI：
--
发表时间：
2015
期刊：
影响因子：
--
作者：
Ishimura N;Izumi D;Mikami H;Shimura S;Aimi M;Uno G;Tanimura T;Oshima N;Furuta K;Fujishiro H;Izumi A;Ishihara S;Adachi K;Kinoshita Y
通讯作者：
Kinoshita Y
影响因子：
5.3
作者：
Kato, Takahiro;Yagi, Nobuaki;Ida, Kazunori
通讯作者：
Ida, Kazunori
早期胃癌合并结节性胃炎一例
DOI：
--
发表时间：
2004
期刊：
影响因子：
--
作者：
T. Kamada;K. Haruma;K. Sugiu;Yuichi Nagashima;D. Qian;H. Koga;M. Takeda;H. Kusunoki;K. Honda;Y. Fujimura;T. Tsunoda;Y. Sadahira
通讯作者：
Y. Sadahira