The changing incidence of thyroid carcinoma in Shenyang, China before and after universal salt iodization.
The changing incidence of thyroid carcinoma in Shenyang, China before and after universal salt iodization.
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DOI：
10.12659/msm.883736
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发表时间：
2013-01-14
期刊：
影响因子：
--
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Dong W;Zhang H;Zhang P;Li X;He L;Wang Z;Liu Y
自1996年在中国全境推行全民食盐加碘以来，甲状腺疾病的患病率随着碘摄入量的增加而增加。本研究的目的是分析中国所在的沈阳市实施统一标准治疗前后甲状腺癌的发病率。病理报告来自中国医科大学第一医院1992-01-01/2009-12-31收治的甲状腺疾病患者。分析各组织学类型甲状腺癌的发现率、构成比、性别、年龄及伴发甲状腺疾病的变化。USI后TC、乳头状甲状腺癌(PTC)、髓样癌(MTC)的检出率升高，滤泡性甲状腺癌(FTC)的检出率降低，未分化甲状腺癌(UTC)的检出率无明显变化。USI后PTC的构成比增加，FTC和UTC的构成比降低，MTC的构成比无变化。女性TC患者的平均年龄在USI后降低。USI后PTC并发结节性甲状腺肿或慢性淋巴细胞性甲状腺炎的发生率增加。USI后TC的检出率显著提高，组织学类型以PTC为主，女性TC患者平均年龄降低。对高碘摄入量下有结节性甲状腺肿或慢性淋巴细胞性甲状腺炎的患者应予以随访。
An increase in the prevalence of thyroid disease has been found with increasing iodine intake, since universal salt iodization (USI) was instituted throughout China in 1996. The aim of this study was to analyze the incidence of thyroid carcinoma (TC) before and after USI in Shenyang, a city of northeastern China. The pathology reports were collected from patients with thyroid diseases who underwent surgery in the First Hospital of China Medical University from January 1, 1992 to December 31, 2009. The detection rate, the constituent ratio, the changes of sex, age, and concomitant thyroid diseases of each histological type of TC were analyzed. The detection rate of TC, papillary thyroid carcinoma (PTC), and medullary thyroid carcinoma (MTC) increased; that of follicular thyroid carcinoma (FTC) decreased; and that of undifferentiated thyroid carcinoma (UTC) showed no change after USI. The constituent ratio of PTC increased, that of FTC and UTC decreased, and that of MTC showed no change after USI. The mean age of female patients with TC decreased after USI. The incidences of PTC complicated with either nodular goiter or chronic lymphocytic thyroiditis increased after USI. The detection rate of TC increased significantly, PTC predominated in the histological types of TC, and the mean age of female patients with TC decreased after USI. The patients with either nodular goiter or chronic lymphocytic thyroiditis under high iodine intake should be followed up.
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