Salmonella acquires ferrous iron from haemophagocytic macrophages.
Salmonella acquires ferrous iron from haemophagocytic macrophages.
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DOI：
10.1111/mmi.12739
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发表时间：
2014-09
影响因子：
3.6
通讯作者：
Detweiler CS
中科院分区：
文献类型：
--
作者：
Nagy TA;Moreland SM;Detweiler CS
Bacteria harbor both ferrous and ferric iron transporters. We now report that infection of macrophages and mice with a Salmonella enterica Typhimurium strain containing an inactivated feoB-encoded ferrous iron transporter results in increased bacterial replication, compared to infection with wild-type. Inactivation of other cation transporters, SitABCD or MntH, did not increase bacterial replication. The feoB mutant strain does not have an intrinsically faster growth rate. Instead, increased replication correlated with increased expression in macrophages of the fepB-encoded bacterial ferric iron transporter and also required siderophores, which capture ferric iron. Co-infection of mice with wild type and a feoB mutant strain yielded a different outcome: FeoB is clearly required for tissue colonization. In co-infected primary mouse macrophages, FeoB is required for S. Typhimurium replication if the macrophages were IFNγ treated and contain phagocytosed erythrocytes, a model for hemophagocytosis. Hemophagocytes are macrophages that have engulfed erythrocytes and/or leukocytes and can harbor Salmonella in mice. These observations suggest that Salmonella acquires ferrous iron from hemophagocytic macrophages.
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作者：
Gonzalez-Escobedo, Geoffrey;Gunn, John S.
通讯作者：
Gunn, John S.
影响因子：
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BUCHMEIER, NA;LIBBY, SJ;FANG, FC
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HEFFRON, F
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